2020
DOI: 10.1158/0008-5472.can-19-1161
|View full text |Cite
|
Sign up to set email alerts
|

CoA Synthase (COASY) Mediates Radiation Resistance via PI3K Signaling in Rectal Cancer

Abstract: Neoadjuvant radiation is standard of care for locally advanced rectal cancer. Response to radiation is highly variable and directly linked with survival. However, there currently are no validated biomarkers or molecular targets to predict or improve radiation response, which would help develop personalized treatment and ideally targeted therapies. Here, we identified a novel biomarker, coenzyme A synthase (COASY), whose mRNA expression was consistently elevated in radioresistant human rectal cancers. This obse… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

1
35
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 37 publications
(36 citation statements)
references
References 57 publications
1
35
0
Order By: Relevance
“…Tissue collection and gene expression profiling have been already described for the rectal cancer cohort [ 72 , 73 , 74 ]. Briefly, tissue samples were obtained from patients with locally advanced rectal cancer patients.…”
Section: Methodsmentioning
confidence: 99%
“…Tissue collection and gene expression profiling have been already described for the rectal cancer cohort [ 72 , 73 , 74 ]. Briefly, tissue samples were obtained from patients with locally advanced rectal cancer patients.…”
Section: Methodsmentioning
confidence: 99%
“…In vitro and in vivo studies proved that increased levels of COASY were directly related to radiation resistance, possible by enhancing DNA repair efficiency and/or by activation of the PI3K/AKT/mTOR pathway. Knocking down COASY resulted in a better radiation response, including delayed tumor growth, inhibited cell proliferation, and increased activation of apoptosis after irradiation [122,123]. It would be interesting to know whether heterogeneity in response to radiation alterations in COASY expression levels is characteristic of other types of cancers.…”
Section: Cancersmentioning
confidence: 99%
“…Identifying reasons for this heterogeneity in response, and discovering novel targets to improve radiation sensitivity will lead to treatment advances. We have recently discovered Coenzyme A synthase (COASY) as a novel protein that serves both as a predictive marker for, and has a critical function in radiation resistance [ 4 ].…”
mentioning
confidence: 99%
“…Mechanistically, we demonstrated a direct interaction between COASY protein and the PI3K regulatory subunit PI3K-P85α, which increased AKT and mTOR phosphorylation, enhancing cell survival after irradiation. Additionally, shRNA COASY -knockdown increased DNA double-strand breaks after irradiation [ 4 ].…”
mentioning
confidence: 99%
See 1 more Smart Citation