Coadministration of a beta-adrenergic antagonist and a tricyclic antidepressant: A pilot study

Tang, Siu Wa; Remington, Gary; Persad, Emmanuel; Rosenblat, Rebecca

doi:10.1016/0165-1781(90)90062-a

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…If necessary, antidepressant medications may be used in combination with ~-blockers.1t has been reported that propranolol does not diminish the clinical effectiveness of desipramine (Tang et al 1990). …”

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confidence: 99%

Drug-Induced Depression

Patten

Love

1994

Drug Safety

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According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R), drug-induced depression may be classified as an Organic Mood Syndrome, Depressed Type. Unfortunately, the DSM-III-R diagnostic criteria are not sufficiently precise for application in research, and studies of drug-induced depression have rarely utilised these criteria. Research concerned with drug-induced depression is characterised by a number of methodological complications. These include differing definitions of depression, including depression defined as a symptom, a syndrome, or by diagnostic criteria for a specific mental disorder. In addition, patients undergoing pharmacological treatments for medical illnesses are typically exposed to considerable psychosocial stress due to the suffering and disability associated with illness. These psychosocial factors may in themselves precipitate episodes of depression. Due to these complicating factors, sophisticated study designs are required to confirm an aetiological role for medications as risk factors for depression. Unfortunately, adequate studies have rarely been conducted, and much of the literature consists of case reports and clinical observations. Consequently, clinicians are frequently required to make clinical judgements about the aetiology of patients' depressive symptoms in the absence of definitive scientific information about the role of drugs. Nevertheless, a knowledge of the relevant literature will assist clinicians in making reasoned judgements about the aetiology, prevention and management of these disorders.

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confidence: 99%

Drug-Induced Depression

Patten

Love

1994

Drug Safety

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Biochemical Effects of Antidepressant Augmentation

Howland¹

1995

Arch Gen Psychiatry

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β-Blockers and Depression

Yudofsky¹

1992

JAMA

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Since their introduction over a quarter of a century ago, \g=b\-adrenergicreceptor antagonists (\g=b\-blockers) have been among the most commonly prescribed and useful of all medications. 1 Beyond their cardiovascular applications in the treatment of hypertension, arrhythmias, and angina pectoris, and for the prophylaxis of myocardial infarctions in those who have suffered a prior myocardial infarction, \g=b\-blockers are currently and increasingly being used for a broad variety of other conditions ranging from performance anxiety, migraine headaches, glaucoma, hyperthyroidism, and hand tremors to the treatment of rage and violent behavior in individuals with brain lesions or injury. Briefly following the introduction of \g=b\-blockers,reports appeared in the medical literature associating their use with clinical depression. One of the earliest and most frequently cited articles reported a 50% incidence of depression in patients who had received 120 mg/d of propranolol hydrochloride for periods extending beyond 3

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Coadministration of a beta-adrenergic antagonist and a tricyclic antidepressant: A pilot study

Cited by 5 publications

References 19 publications

Drug-Induced Depression

Drug-Induced Depression

Biochemical Effects of Antidepressant Augmentation

β-Blockers and Depression

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