Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistance

Quain, Rhonda D.; Barton, Todd D.; Fishman, Neil O.; Weiner, Mark G.; Lautenbach, Ebbing

doi:10.1016/j.ijantimicag.2005.04.021

Cited by 15 publications

(11 citation statements)

References 10 publications

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“…A case control study suggested that di- and trivalent cation-containing compounds (DTCCs), including multivitamins, might inhibit fluoroquinolone absorption [260]. Also interactions with OTC preparations such as Centrum Forte ® , containing Fe 2+ , Mg 2+ , Zn 2+ , Ca 2+ , Cu 2+ and Mn 2+ , are observed, resulting in a decrease in C max and AUC by 55% [251].…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

et al. 2011

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Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well as concomitantly administered drugs. Since knowledge about mechanisms is of paramount importance for adequate management of drug interactions, the most plausible underlying mechanism of the drug interaction is provided when available. This overview can be used in daily practice to support the management of pharmacokinetic drug interactions of antimicrobial drugs.

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Section: Resultsmentioning

confidence: 99%

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

et al. 2011

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“…Investigações buscando elucidar os fatores desencadeantes dessa resistência verificaram que a redução das concentrações plasmáticas devida à diminuição da absorção por interação com cátions diou trivalentes pode explicá-la (Quain et al, 2005. Os erros de horário podem levar à ocorrência de interações que comprometem a absorção, pois aumentam a probabilidade de co-administração de medicamentos.…”

Section: Resultsunclassified

Erros de administração de antimicrobianos identificados em estudo multicêntrico brasileiro

Marques¹,

Reis²,

Silva³

et al. 2008

Rev. Bras. Cienc. Farm.

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“…26,27 Data obtained included age, sex, race, the hospital of admission (ie, HUP or PPMC), origin at the time of hospital admission (eg, home or transfer from another facility), hospital location at the time of infection (eg, intensive care unit [ICU] or medical floor), and number of hospital and ICU-days prior to infection. The presence of the following comorbid conditions was documented: diabetes mellitus, renal insufficiency (creatinine level >2.0 mg/dL or the requirement of hemodialysis), malignancy, prior organ transplantation, human immunodeficiency virus, neutropenia (absolute neutrophil count <500/mm 3 ), and use of an immunosuppressive agent or steroids in the 30 days prior to infection.…”

Section: Methodsmentioning

confidence: 99%

Prior Vancomycin Use Is a Risk Factor for Reduced Vancomycin Susceptibility in Methicillin-Susceptible but Not Methicillin-Resistant Staphylococcus aureus Bacteremia

Mascitti

Edelstein

Fishman

et al. 2012

Infect. Control Hosp. Epidemiol.

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OBJECTIVE Staphylococcus aureus is a cause of community- and healthcare-acquired infections and is associated with substantial morbidity, mortality, and costs. Vancomycin minimum inhibitory concentrations (MICs) among S. aureus have increased, and reduced vancomycin susceptibility (RVS) may be associated with treatment failure. We aimed to identify clinical risk factors for RVS in S. aureus bacteremia. DESIGN Case-control. SETTING Academic tertiary care medical center and affiliated urban community hospital. PATIENTS Cases were patients with RVS S. aureus isolates (defined as vancomycin E-test MIC >1.0 μg/mL). Controls were patients with non-RVS S. aureus isolates. RESULTS Of 392 subjects, 134 (34.2%) had RVS. Fifty-eight of 202 patients (28.7%) with methicillin-susceptible S. aureus (MSSA) isolates had RVS, and 76 of 190 patients (40.0%) with methicillin-resistant S. aureus (MRSA) isolates had RVS (P =.02). In unadjusted analyses, prior vancomycin use was associated with RVS (odds ratio [OR], 2.08; 95% confidence interval [CI], 1.00–4.32; P =.046). In stratified analyses, there was significant effect modification by methicillin susceptibility on the association between vancomycin use and RVS (P = .04). In multivariable analyses, after hospital of admission and prior levofloxacin use were controlled for, the association between vancomycin use and RVS was significant for patients with MSSA infection (adjusted OR, 4.02; 95% CI, 1.11–14.50) but not MRSA infection (adjusted OR, 0.87; 95% CI, 0.36–2.13). CONCLUSIONS A substantial proportion of patients with S. aureus bacteremia had RVS. The association between prior vancomycin use and RVS was significant for patients with MSSA infection but not MRSA infection, suggesting a complex relationship between the clinical and molecular epidemiology of RVS in S. aureus.

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Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistance

Cited by 15 publications

References 10 publications

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams

Erros de administração de antimicrobianos identificados em estudo multicêntrico brasileiro

Prior Vancomycin Use Is a Risk Factor for Reduced Vancomycin Susceptibility in Methicillin-Susceptible but Not Methicillin-Resistant Staphylococcus aureus Bacteremia

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