Coadministration of Orally Inhaled Zanamivir with Inactivated Trivalent Influenza Vaccine Does Not Adversely Affect the Production of Antihaemagglutinin Antibodies in the Serum of Healthy Volunteers

Webster, Alison; Boyce, Malcolm; Edmundson, Sally; Miller, Irene

doi:10.2165/00003088-199936001-00006

Cited by 48 publications

(14 citation statements)

References 11 publications

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“…Chief among these additional measures is the concurrent administration of inactivated influenza vaccine parenterally. Zanamivir does not interfere with the hemagglutination antibody response to injected vaccine (91). A similar lack of interference with oseltamivir would be expected.…”

Section: Chemoprophylaxis Versus Early Therapysupporting

confidence: 56%

The Use of Antiviral Drugs for Influenza: Guidance for Practitioners 2012/2013

Aoki

Allen²,

Stiver³

et al. 2012

Canadian Journal of Infectious Diseases and Medical Microbiolog

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The present article addresses the use of antiviral drugs in the management of seasonal influenza illness for the 2012/2013 season. It updates the previous document published in 2011 (1). Noteworthy guidance updates since 2011 include the following: Seasonal influenza in 2012/2013 is predicted to be caused by two human influenza A and one influenza B strain, all of which are anticipated to remain generally susceptible to oseltamivir.The predicted strains are A/California/7/2009 (H1N1) pdm09-like, A/Victoria/361/2011 (H3N2)-like and B/Wisconsin/1/2010-like (Yamagata lineage). All are included in the seasonal influenza vaccine and are susceptible to oseltamivir.Swine-variant H3N2v, which has rarely caused infection in humans exposed to infected swine within the past year in the United States, is susceptible to oseltamivir. It is not included in the current seasonal influenza vaccine.It is still considered that initiation of antiviral therapy more than 36 h to 48 h after onset of symptoms is beneficial in patients hospitalized with complicated influenza and severe illness.Oseltamivir continues to be recommended for the treatment of influenza in pregnant women.The use of antiviral drugs among measures to control outbreaks of influenza in closed facilities such as correctional institutions is now included in the present document.

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Section: Chemoprophylaxis Versus Early Therapysupporting

confidence: 56%

The Use of Antiviral Drugs for Influenza: Guidance for Practitioners 2012/2013

Aoki

Allen²,

Stiver³

et al. 2012

Canadian Journal of Infectious Diseases and Medical Microbiolog

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show abstract

“…Zanamivir does not impair the humoral immune response to inactivated influenza vaccine. 28 Our findings indicate that prophylaxis with zanamivir is an effective option for preventing the transmission of influenza within households. Further studies of prophylactic administration of inhaled zanamivir in other high-risk groups, such as severely immunocompromised patients who are unlikely to have a response to vaccine or residents of nursing homes or other institutions in which there are outbreaks of influenza, are warranted.…”

Section: Discussionmentioning

confidence: 66%

Inhaled Zanamivir for the Prevention of Influenza in Families

et al. 2000

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“…There is no effect on the immune response to vaccination when zanamivir is co-administered with influenza vaccine [111]. Similarly, the immune response to influenza infection is unaffected by treatment with oseltamivir in clinical trials [112].…”

Section: Drug Interactionsmentioning

confidence: 99%

Anti-influenza drugs and neuraminidase inhibitors

Roberts¹

2001

Progress in Drug Research

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Coadministration of Orally Inhaled Zanamivir with Inactivated Trivalent Influenza Vaccine Does Not Adversely Affect the Production of Antihaemagglutinin Antibodies in the Serum of Healthy Volunteers

Cited by 48 publications

References 11 publications

The Use of Antiviral Drugs for Influenza: Guidance for Practitioners 2012/2013

The Use of Antiviral Drugs for Influenza: Guidance for Practitioners 2012/2013

Inhaled Zanamivir for the Prevention of Influenza in Families

Anti-influenza drugs and neuraminidase inhibitors

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