Coagulant Activity of Leukocytes. TISSUE FACTOR ACTIVITY

Niemetz, Julian

doi:10.1172/jci106815

Cited by 172 publications

(57 citation statements)

References 26 publications

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“…Endotoxin-treated animals had fibrin deposits in glomerular capillary loops 5 h after starting the experiment and also had an increase in the neutrophil procoagulant content. Endotoxin increases the neutrophil procoagulant content (2 1,30) and this can activate the coagulation cascade (30). These findings suggest but do not prove a sequence in which activated neutrophils may be augmenting a localized coagulation propess.…”

Section: Discussionmentioning

confidence: 94%

Neutrophil Function in an Experimental Model of Hemolytic Uremic Syndrome

1987

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Section: Discussionmentioning

confidence: 94%

Neutrophil Function in an Experimental Model of Hemolytic Uremic Syndrome

1987

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“…[15][16][17][18][19][20] Leukocytes are actively recruited into growing arterial thrombi by platelet P-selectin-mediated cell-cell interactions and can support the thrombin generation. [21][22][23][24][25][26] Although lymphocytes do not appear to accumulate in thrombi, they were the only leukocyte subtype that was significantly correlated with substrate platelet deposition. 27 Lymphocytes have been shown to influence monocyte tissue factor expression in humans.…”

Section: Discussionmentioning

confidence: 99%

Factors Contributing to Individual Propensity for Arterial Thrombosis

Karnicki

Owen

Miller

et al. 2002

ATVB

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Objective-Occurrence of arterial thrombosis secondary to vascular disease in an individual is not easily predicted. After establishing that this poor predictability arises at least in part from an intrinsic thrombosis propensity of the individual, we sought to determine whether the propensity for arterial thrombosis is governed by blood or arterial wall factors. Methods and Results-To evaluate the variability arising from the blood, autologous 111 In-labeled platelet deposition was measured after high-shear perfusion of compressed aortic strips, prepared from a single pig, with heparinized blood from 25 pigs. To evaluate the variability arising from the vessel wall, aortic strips from 8 pigs were superfused with blood from a single animal. Blood samples from 25 animals superfused over aortic substrate from a single source yielded a 24-fold range of platelet deposition. In contrast, when aortic substrates from 8 different animals were superfused with blood from a single animal, platelet deposition spanned a 3-fold range. Platelet deposition was significantly correlated with whole-blood lymphocyte counts and with platelet counts. Conclusions-Individual propensity for arterial thrombosis in pigs is more greatly influenced by blood components than by elements within the arterial wall.

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“…A more specific assay for tissue thromboplastin thani the one-stage test with normal plasma was performed (20,21). 0.1 ml of the resuspended leukocyte incubate wvas added to 0.1 ml of a bariu-m sulfate eluate of normal hum-an serum.…”

Section: Methodsmentioning

confidence: 99%