Coagulant and anticoagulant activities in Jatropha curcas latex

Osoniyi, Omolaja; Onajobi, Funmi

doi:10.1016/s0378-8741(03)00263-0

Cited by 109 publications

(59 citation statements)

References 7 publications

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“…anticoagulant, coagulant (Osoniyi & Onajobi, 2003); neuroprotective (Kulkarni et al, 2005); causes nausea and vomiting (AbduAguye et al, 1986). (Schultes, 1979).…”

Section: -21 Elephantopus Mollismentioning

confidence: 99%

Brazilian plants with possible action on the central nervous system—A study of historical sources from the 16th to 19th century

Giorgetti

Negri

Rodrigues

2007

Journal of Ethnopharmacology

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Ethnopharmacological research when grounded on historic literature has for its objective retrieving traditional knowledge compiled throughout history by early cultures. The current study has used literature from the 16 th to the 19 th centuries to assess reports that include accounts of Brazil's native plants, with possible reports of disorders of the Central Nervous System (CNS). Visits were paid to 27 institutions located in four Brazilian states. This resulted in raising 529 publications, out of which 65 were read, revealing that 33 of them contained reports of plants exerting effects on CNS ailments. These plants' scientific names underwent an updating process. The updating process resulted in 788 species names (129 correct scientific names and their 659 synonyms) out of which 66 hold current ethnopharmacology, pharmacology studies and/or patent application. Coincidences among past and present data have been observed in 46 cases. Only three of them carried applications for patents all of which coincided with past uses. There have hardly been any studies whatsoever throughout the centuries for many of the species currently being studied. Although of very seldom use, research in ethnopharmacology and historic literature can be promising tools for the selecting of new pharmaco products, further to contributing with retrieving traditional knowledge.

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“…anticoagulant, coagulant (Osoniyi & Onajobi, 2003); neuroprotective (Kulkarni et al, 2005); causes nausea and vomiting (AbduAguye et al, 1986). (Schultes, 1979).…”

Section: -21 Elephantopus Mollismentioning

confidence: 99%

Brazilian plants with possible action on the central nervous system—A study of historical sources from the 16th to 19th century

Giorgetti

Negri

Rodrigues

2007

Journal of Ethnopharmacology

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“…In addition to popular use, studies have shown that physic nut latex exhibits anticoagulant activity (Osonlyi and Anajobi 2003). Moreover, phytochemical analyses demonstrate that the latex of this species contains natural components with cytotoxic potential, including curcacyclins A and B (Insanu et al 2012) and curcusomes A, B, C and D (Aiyelaagbe et al 2011); anticancerous compounds, such as the protein curcin (JaramilloQuintero et al 2015) and the alkaloids jatrophine and jatropham (Thomas et al 2008); and antibactericidal and antimalarial compounds, such as curcacyclins A and B and jatrophidin (Sabandar et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Factors that influence in Jatropha curcas L. latex production

et al. 2017

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ABSTRACT:Latex from Jatropha curcas L. exhibits biotechnological potential for the development of biodiesel and drugs. Little is known about the collection methods and latex productivity of this species.In order to garner information on the use of J. curcas latex, factors that influence production by this species were assessed. As a result, no significant difference was found between the volume of latex production. Multiple regression analysis demonstrated that latex production is positively associated with plant height and negatively associated with fruit production and other variables that maximize it. During the fruiting process the plant uses most of the assimilates for fruit development and a lower percentage to produce secondary compounds, resulting in less availability of these metabolites for latex production. In general, the latex production obtained from this species is low and limits commercial exploitation of this compound, despite its possible pharmacological potential.

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“…2,3 Thus J. curcas seeds have acquired importance for its extra-medicinal properties 4 and its use in native communities for some conditions as arthritis, gout, jaundice, convulsions, constipation, diarrhea, fever and inflammation. 3,5,6 In Peru, this plant is located in departments of Lima, Piura, Cajamarca, San Martin, Cusco, Ucayali and Loreto where its traditional practices were also recognised. 3,7,8 Preclinical studies have demonstrated the biological activity of the different parts of J. curcas, so, antifungal and acaricide activity of seeds; [9][10][11][12][13] antidiarrheal, anti inflammatory and antimicrobial effect of the root, stem, bark and leaf; 3,14-17 abortifacient activity of fruit 18 and activity on the blood coagulation of latex.…”

Section: Introductionmentioning

confidence: 99%

“…3,7,8 Preclinical studies have demonstrated the biological activity of the different parts of J. curcas, so, antifungal and acaricide activity of seeds; [9][10][11][12][13] antidiarrheal, anti inflammatory and antimicrobial effect of the root, stem, bark and leaf; 3,14-17 abortifacient activity of fruit 18 and activity on the blood coagulation of latex. 6 These recognized effects of J. curcas might be supported by presence of secondary metabolites as alkaloids, flavonoids, esters, lectins, tannins, saponins, terpenoids, lipases, among others. [19][20][21][22][23] In addition, there are validated methods to evaluate effects on the nervous system and inflammatory activity as Irwin test and Carrageenaninduced paw oedema test, which were used to validate pharmacological effects of some medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Study on Inflammation and the Nervous system of Ethanol extract of Jatropha Curcas seed

Zambrano-Huailla¹,

Zambrano-Huailla²,

Sergio³

et al. 2016

Phcogj

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Introduction: Jatropha curcas L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim of this study is to evaluate effects on inflammation and the nervous system of ethanol extract of J. curcas seeds. Materials and methods: It was used 64 mice divided in 8 groups; respectively, 4 groups received 400, 600, 800 and 1000 mg/kg of ethanol extract of J. curcas seed; and the rest intake Diclofenac, Diazepam, Caffeine and a control group not received any substance. The effects on inflammation was evaluated by Carrageenan-Induced paw oedema test and by Paw skin temperature. Neurological symptoms of toxicity were evaluated using the Irwin test. For the analysis of quantitative variables were used the following tests: one-way ANOVA, Tukey, Shapiro-Wilk and Pearson correlation; for qualitative variables Chi square was used. Results: According to the paw oedema, it was showed a trend on an inflammatory effect of the seeds of J. curcas; this activity was statistically significant in doses of 1000 mg/kg. Also, the skin temperature measurements out-

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Coagulant and anticoagulant activities in Jatropha curcas latex

Cited by 109 publications

References 7 publications

Brazilian plants with possible action on the central nervous system—A study of historical sources from the 16th to 19th century

Brazilian plants with possible action on the central nervous system—A study of historical sources from the 16th to 19th century

Factors that influence in Jatropha curcas L. latex production

Study on Inflammation and the Nervous system of Ethanol extract of Jatropha Curcas seed

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