Coagulase-Negative Staphylococci and Their Role in Infection

Gemmell, C. G.; Lang, Susan

doi:10.1016/b978-0-12-397169-2.00043-3

Cited by 3 publications

(2 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S. epidermidis is one of the major causes of nosocomial infections, especially nosocomial bacteraemia. It expresses several virulence factors including those involved in the ability to adhere to and accumulate as a biofilm on a variety of surfaces, including prosthetic devices and transcutaneous catheters [20]. Enterococcus species are natural members of the human and warmblood animal intestinal flora.…”

Section: Microbiological Properties Of 2-pyrrolidonementioning

confidence: 99%

Studies on the Evaluation of Preservative Efficacy of 2-Pyrrolidone for Oral Paediatric Formulations

2018

J Pharmacol Pharm Res

View full text Add to dashboard Cite

Pharmaceutical oral dosage forms intended to children have to be administered under liquid dosage forms. These oral liquid formulations contained into multidose containers require the addition of antimicrobial agents to avoid the growth of microorganisms. Moreover, the oral administration of poorly water soluble drugs requires the use of excipients (organic solvent, cyclodextrins, surfactants, polymers) able to improve their water solubility. 2-pyrrolidone (Soluphor ® P) a co-solvent usually used to dissolve drugs for the manufacture of parenteral dosage forms and suggested also for other administration routes, showed antimicrobial activity. To study the extent of its preservative efficacy, we determined the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) first, for bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus capitis) and for bacterial spores (Bacillus cereus, Bacillus sphaericus, Bacillus subtilis), then for yeast and mould (Candida albicans, Aspergillus niger). The results showed that 2-pyrrolidone has a bactericidal and fungistatic efficacy. Challenge tests were realized on oral aqueous paediatric formulations of vitamin D3 containing 2-pyrrolidone as a co-solvent and all known micro-organisms in such formulations were studied. The preservative efficacy of 2-pyrrolidone was observed at a dosage level of 75 mg/mL.

show abstract

Section: Microbiological Properties Of 2-pyrrolidonementioning

confidence: 99%

Studies on the Evaluation of Preservative Efficacy of 2-Pyrrolidone for Oral Paediatric Formulations

2018

J Pharmacol Pharm Res

View full text Add to dashboard Cite

show abstract

“…The ability of CNS to form a biofilm, mainly on the surface of foreign bodies in the human organism but also on the surface of tissues, plays the most important role in the pathogenesis of CNSinduced infections (8,14). The study of CNS pathogenicity has also shown that various metabolites are produced by these microorganisms, including enzymes and toxins which may play a role in the pathogenicity of these microorganisms (15), such as lipases, proteases, other exoenzymes, which possibly contribute to the persistence of CNS in the host and may degrade host tissues and the production of hemolysin, , DNAse, and TNAse (7,13).…”

Section: Introductionmentioning

confidence: 99%

Virulence Characterization of Coagulase-Negative Staphylococci Isolated from Sexually Active Women with Symptomatic Genital Tract Infection, In Comparison with Staphylococcus aureus Isolated from the Same Cases

Al-Mayahie

2022

JWSM

View full text Add to dashboard Cite

This study included 33 coagulase-negative staphylococci (CNS) and 35 Staphylococcus aureus isolated from sexually active females with symptomatic genital tract infection (64 pregnant and 110 non-pregnant). Comparison of phenotypic characteristics showed that the difference is not significant between CNS and S. aureus isolates for hemolytic activity (63.6% and 54.2%, respectively); lipolytic activity (87.8% and 88.5%, respectively); protease production (18.1% and 31.4%, respectively). and biofilm formation ( 96.9% and 94.2%, respectively). Whereas the difference is significant (P≤ 0.05) for urease production (18.1% and 42.8%, respectively). With the exception of lipolytic activity and biofilm formation, co-expression of other factors showed that there was an opposite expression of hemolytic and proteolytic activities of both CNS and S. aureus isolates. For CNS only 3/33 (9%) of the isolates were hemolytic and preoteolytic while for S. aureus only 2/35 (5.7%) isolates had this characteristics. Also for S. aureus isolates, ureolytic activity was more correlated with hemolytic (20%) and proteolytic (11.4%) activities than in CNS (6.0% and 3.0%, respectively). We concluded that, for this study included factors, the virulence of CNS isolated from females' genital tract infection is comparable to that of the potential females' genital tract pathogen, S. aureus. So that, CNS can be opportunistic pathogens in these cases rather than mere contaminants.

show abstract

Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteers

Gustafsson

Cars²,

Andersson³

2003

Journal of Antimicrobial Chemotherapy

View full text Add to dashboard Cite

show abstract

Coagulase-Negative Staphylococci and Their Role in Infection

Cited by 3 publications

References 136 publications

Studies on the Evaluation of Preservative Efficacy of 2-Pyrrolidone for Oral Paediatric Formulations

Studies on the Evaluation of Preservative Efficacy of 2-Pyrrolidone for Oral Paediatric Formulations

Virulence Characterization of Coagulase-Negative Staphylococci Isolated from Sexually Active Women with Symptomatic Genital Tract Infection, In Comparison with Staphylococcus aureus Isolated from the Same Cases

Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteers

Contact Info

Product

Resources

About