Coagulation Abnormalities in Acute Pancreatitis

Gould, Travis J.; Mai, Safiah; Liaw, Patricia C.

doi:10.5772/30169

Cited by 6 publications

(13 citation statements)

References 75 publications

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“…This is in contrast to previous studies, where higher mortality and multiple organ failure were found to be associated with abnormal procoagulation parameters [ 12 , 26 ]. We found prolongation of PT in most (97.6%) of the patients and prolonged aPTT in only few (4.8%) patients, consistent with previous studies [ 27 , 28 ]. Prolongation of PT may be secondary to disseminated intravascular coagulation (DIC), associated with severity inflammatory processes such as pancreatitis; or it may be secondary to impaired hepatic synthetic function caused by cytokine as a part of SIRS.…”

Section: Discussionsupporting

confidence: 92%

Role of thrombophilia in splanchnic venous thrombosis in acute pancreatitis

Ahmed¹,

Rana²,

Ahluwalia³

et al. 2018

aog

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Background:Splanchnic venous thrombosis (SVT) is a common vascular complication of acute pancreatitis (AP). We conducted this study to prospectively investigate the frequency, risk factors, and extent of SVT in patients with AP and to evaluate the role of thrombophilia in its causation.Methods:Patients with AP presenting between January 2015 and June 2016 were prospectively evaluated with contrast-enhanced computed tomography (CT) for the presence of SVT. These patients underwent a detailed analysis of coagulation parameters.Results:We evaluated 96 patients with AP (73 male, mean age 31.85±13.34 years), of whom 26 (27.1%) had SVT. Splenic vein, portal vein, and superior mesenteric vein involvement were seen in 22 (84.6%), 11 (42.3%), and 4 (15.3%) patients, respectively. Necrotizing pancreatitis, CT severity index (CTSI) >6 and modified CTSI >6 were significantly more frequent in patients with SVT than in those without (96.2% vs. 78.6%, 76.9% vs. 47.1%, and 92.3% vs. 67.1%, respectively). Proteins C and S, and antithrombin III deficiency were found in 23.8%, 33.3% and 31.0% of patients, respectively. Anti-β2-glycoprotein I and lupus anticoagulant were positive in 4.8% and 11.9% of patients, respectively. Factor V Leiden mutation analysis was positive in 6.1% of patients. Coagulation abnormality did not differ significantly between the patients with and without SVT.Conclusions:SVT is more common in patients with necrotizing pancreatitis, suggesting that local inflammation plays a major role in its causation. Thrombophilia is seen in one third of patients with AP but does not seem to increase the risk of SVT.

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Section: Discussionsupporting

confidence: 92%

Role of thrombophilia in splanchnic venous thrombosis in acute pancreatitis

Ahmed¹,

Rana²,

Ahluwalia³

et al. 2018

aog

View full text Add to dashboard Cite

show abstract

“…This is in contrast to previous studies, where higher mortality and multiple organ failure were found to be associated with abnormal procoagulation parameters [12,26]. We found prolongation of PT in most (97.6%) of the patients and prolonged aPTT in only few (4.8%) patients, consistent with previous studies [27,28]. Prolongation of PT may be secondary to disseminated intravascular coagulation (DIC), associated with severity inflammatory processes such as pancreatitis; or it may be secondary to impaired hepatic synthetic function caused by cytokine as a part of SIRS.…”

Section: Discussioncontrasting

confidence: 57%

Role of Thrombophilia in Splanchnic Venous Thrombosis in Acute Pancreatitis

Ahmed¹,

Rana²,

Ahluwalia³

et al. 2017

Gastroenterology

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“…Studies have shown that complications related to hemostatic disorders are some of the causes of such a high mortality rate among patients with AP. Despite the fact that numerous experimental proofs suggest an important role of the coagulation system in AP, studies concern-ing the clinical significance of parameters of the coagulation system for predicting complications due to pancreatitis are still very rare [22].…”

Section: Discussionmentioning

confidence: 99%