Coagulation and anticoagulation in the intraoperative setting

Levi, Marcel; Sivapalaratnam, Suthesh

doi:10.1016/j.transci.2019.06.013

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…However, coagulation is a cascade of complex biochemical processes involving interactions between platelets, red blood cells, and over a dozen coagulation factors, as well as two distinct coagulation pathways-endogenous and exogenous [8][9][10]. Conventional coagulation tests (CCTs) generally assess the coagulation status of patients by measuring the activated thromboplastin time (aPTT), prothrombin time (PT), platelet count (PLT), and fibrinogen levels, which require much time to separate plasma, platelets, and other components from whole blood [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Blood Coagulation by Optical Vortex Tracking

Zhang

Gong

Zhang

et al. 2022

Sensors

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Blood coagulation is a complicated dynamic process that maintains the blood’s fluid state and prevents uncontrollable bleeding. The real-time monitoring of coagulation dynamics is critical for blood transfusion guidance, emergency management of trauma-induced coagulopathy, perioperative bleeding, and targeted hemostatic therapy. Here, we utilize optical vortex dynamics to detect the blood coagulation dynamic process in a rapid and non-contact manner. To characterize the temporal changes in viscoelastic properties of blood during coagulation, we track the stochastic motion of optical vortices in the time-varying speckles reflected from 100 blood samples with varied coagulation profiles. The mean square displacement (MSD) of the vortices increases nonlinearly with time lag during blood coagulation reminiscent of the particles in viscoelastic fluids. The MSD curves with coagulation time are similar to the tracings of thromboelastography (TEG) during the blood coagulation. The retrieved coagulation parameters, such as reaction time and activated clotting time measured using the optical vortex method, exhibit a close correlation to those parameters acquired from TEG. These results demonstrate the feasibility of the optical vortex method for monitoring blood coagulation at the point of care. Our method is also applicable to measuring the viscoelasticity of complex fluids and turbid soft matters.

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