Coagulation and cancer: Implications for diagnosis and management

Loreto, M. F.; Martinis, Massimo De; Corsi, M; Modesti, Marco; Ginaldi, Lia

doi:10.1007/bf03187336

Cited by 45 publications

(38 citation statements)

References 104 publications

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“…17 Both experimental data and clinical investigations have revealed that platelets and thrombin promote hematogenous metastasis. [17][18][19][20][21][22][23][24][25] Cancer cells produce tissue factors and procoagulant factors that activate the extrinsic coagulation pathway. 21,22 Surface adhesion molecules and b3 integrins in particular have a major role in mediating these specific interactions.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20][21][22][23][24][25] Cancer cells produce tissue factors and procoagulant factors that activate the extrinsic coagulation pathway. 21,22 Surface adhesion molecules and b3 integrins in particular have a major role in mediating these specific interactions. 24 However, activation of factor X results when tumor cells react with factor VII and this process results in the production of thrombin-tumor cell complexes.…”

Section: Discussionmentioning

confidence: 99%

“…24 However, activation of factor X results when tumor cells react with factor VII and this process results in the production of thrombin-tumor cell complexes. 21,22 The presence of thrombus is essential for stabilization of intravascular tumor cells and implantability. 17 Moreover, it has been demonstrated that It is therefore important to identify fibrin-tumor cell thrombus in areas of vascular invasion.…”

Section: Discussionmentioning

confidence: 99%

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Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation

2011

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There are many controversies involving the diagnostic criteria and treatment of well-differentiated thyroid carcinoma. Vascular invasion has been identified as an important and independent prognosticator in many cancers. The majority of pathologists recognize the importance of vascular invasion as a diagnostic marker of malignancy in follicular lesions of thyroid; however, several reports have suggested that angioinvasion is not a predictor of bad prognosis in thyroid carcinomas. We suggest that the criteria for diagnosing angioinvasion in thyroid carcinomas as well as in other endocrine tumors are inconsistent and the controversy may be attributed to application of inappropriate criteria. We carried out a study of a potential cause of artefactual vascular invasion in a series of autopsy thyroids and established the morphology of mimics of angioinvasion. We then reviewed retrospectively the clinicopathological features of a series of 4000 thyroid carcinomas of follicular epithelial derivation to identify the features and significance of the most rigid criteria of vascular invasion: tumor cells invading through a vessel wall and thrombus adherent to intravascular tumor. These features were identified in 118 (3%) lesions. Follow-up information was available for 98 patients. Of these, 35% developed distant metastases. When using the rigid criteria, B1/3 of angioinvasive well-differentiated thyroid carcinomas and 1/2 of angioinvasive poorly differentiated thyroid carcinomas developed distant metastases at a mean 5.3 years of follow-up. Our results indicate that the application of rigid criteria for vascular invasion provide a clinically relevant prediction of distant metastasis in patients with thyroid carcinomas, especially in well-differentiated thyroid carcinomas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation

2011

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“…Раковый про-коагулянт экспрессируется опухолевыми клет-ками и эмбриональной тканью [2,8]. Кроме то-го, опухолевые клетки активируют прокоагу-лянтное звено системы гемостаза за счет обра-зования рецептора фактора V. Этот рецептор появляется на поверхности плазменной мемб-раны опухолевой клетки и ускоряет формиро-вание протромбиназного комплекса (фактор V + фактор X + кальций + тромбоциты).…”

Section: артериальные и венозные тромбозыunclassified

“…Нарушение регулирующего дей-ствия эндотелия снижает синтез компонентов противосвертывающей системы -антитром-бина III и протеина С печенью. Указанные изме-нения ведут к усилению прокоагулянтной и снижению антикоагулянтной и фибринолити-ческой активности стенки сосудов, что имеет существенное значение в формировании сосу-дистых тромбов [8,10]. Наряду с прокоагулянт-ной активностью моноцитов и эндотелиальных клеток, опухолевые клетки или циркулирующие опухолевые мембраны воздействуют на тром-боцитарное звено системы гемостаза, повышая адгезию и агрегацию тромбоцитов.…”

Section: артериальные и венозные тромбозыunclassified

Thromboses in Oncology. Part 1

Федоткина¹,

Панченко²

2017

Aterotromboz

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Plasma marker proteins associated with the progression of lung cancer in obese mice fed a high‐fat diet

et al. 2012

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Recent studies have indicated that obesity increases the risk of developing several types of cancers including lung cancer, which is the leading cause of cancer death worldwide. In the present study, we attempted to discover marker proteins associated with lung cancer progression mediated by treatment of a high‐fat diet (HFD) using 2DE combined with MALDI‐TOF‐MS. Image analysis and further statistical analysis allowed for the detection and identification of 14 proteins, which consequently were classified into two groups based on their regulation patterns in response to diet and tumor. Interestingly, the protein abundances of ten proteins exhibited a synergistic effect when treated with HFD in tumor‐bearing mice (Group I). Proteins that had a higher abundance in the plasma of tumor‐bearing mice included FGB, Tf, Hpx, Cp, and Hp and the proteins that had a lower abundance included A1AT precursor, PON1, TTRt, and α2‐M. These proteins can be used as molecular markers that contribute simultaneously to both obesity and cancer. Four other proteins showed an increase (complement C3 and FGA) or decrease (Apo H and AT III precursor) in the only tumor‐bearing mice independently of diet (Group II). The marker proteins identified here may lead to the development of new therapeutics for obesity‐causative treatment of lung cancer.

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Coagulation and cancer: Implications for diagnosis and management

Cited by 45 publications

References 104 publications

Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation

Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation

Thromboses in Oncology. Part 1

Plasma marker proteins associated with the progression of lung cancer in obese mice fed a high‐fat diet

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