Coagulation and fibrinolysis during the infusion of Corynebacterium parvum in man

Cederholm‐Williams, S.A.; King, Alexander H.; Allington, M. J.; Gill, P. Grantley; Sharp, A. A.; Britton, B. J.

doi:10.1038/bjc.1978.155

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…There is evidence that C. parvum injection results in DIe in mice [33,42], rats [29], and man [5]. Accompanying DIC are changes in circulating levels of coagulation components, which reflect their consumption and synthesis.…”

Section: Discussionmentioning

confidence: 99%

“…A weight-related dose (14mg/kg) considerably higher than the human dose [5] 24 h, 2, 4, 7, 10, 14, 21 days) groups of five or six rats were anaesthetised with ether and exsanguinated. Formalin-killed strain CN6134 (batch numbers BA 3935/A, CA 732, and CA 749) was obtained from Wellcome Reagents Ltd., Beckenham, Kent, England, at a concentration of 7 mg dry weight washed micro-organism per ml pyrogen-free physiological saline with 0.01% thiomersal as preservative.…”

Section: Methodsmentioning

confidence: 99%

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Serological changes following a single intravenous Corynebacterium parvum injection in the rat

Mauchline¹,

Thomson²,

Johnston³

et al. 1980

Cancer Immunol Immunother

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Serological changes following a single intravenous Corynebacterium parvum injection in the rat

Mauchline¹,

Thomson²,

Johnston³

et al. 1980

Cancer Immunol Immunother

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In Vitro Generation of Procoagulant Activity by Corynebacterium parvum-Stimulated Mononuclear Leukocytes

Miragliotta

Marcuccio

Ricci

et al. 1985

Journal of Leukocyte Biology

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Thromboembolic complications are known in cancer patients after i.v. administration of Corynebacterium parvum. We examined the ability of this organism to induce production of procoagulant activity by human blood mononuclear leukocytes in vitro. After 4 hours incubation Corynebacterium parvum was an effective stimulant for mononuclear leukocytes, behaving in the same way as the typical gram-negative bacterium Escherichia coli, whereas mononuclear cells incubated with Staphylococcus aureus were not affected. Corynebacterium parvum used was found devoid of endotoxin by the Limulus assay and was not affected by Polymyxin B, which, on the contrary, inhibited Escherichia coli-induced production of procoagulant activity. Intact Corynebacterium parvum may be required for the production of procoagulant activity and, although this specific aspect of the research will require further study, from the exposed data it is concluded that such a production could be a factor contributing to the pathogenesis of the coagulopathy following Corynebacterium parvum therapy.

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Disseminated intravascular coagulation following intravenous Corynebacterium parvum injection in the rat

Johnston

Thomson

Simpson

1980

Cancer Immunol Immunother

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Coagulation and fibrinolysis during the infusion of Corynebacterium parvum in man

Cited by 7 publications

References 10 publications

Serological changes following a single intravenous Corynebacterium parvum injection in the rat

Serological changes following a single intravenous Corynebacterium parvum injection in the rat

In Vitro Generation of Procoagulant Activity by Corynebacterium parvum-Stimulated Mononuclear Leukocytes

Disseminated intravascular coagulation following intravenous Corynebacterium parvum injection in the rat

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