Coagulation changes after an experimental missile wound to the brain in the cat

Awasthi, Deepak; Rock, William; Carey, Michael E.; Farrell, J B

doi:10.1016/0090-3019(91)90157-5

Cited by 13 publications

(3 citation statements)

References 22 publications

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“…7 In the United States, 35,000 deaths per year result from gunshot in-juries 8 and 6000 deaths from traumatic brain injuries. 12 Late complications are posttraumatic hydrocephalus, intracranial infections, and epilepsy. In gunshot wounds, as in other forms of penetrating head injuries, a primary lesion can be distinguished from secondary insultsVeither originating from intracranial or from extracranial causes (eg, hypoxia, hypercapnia, hypertension).…”

Section: Discussionmentioning

confidence: 99%

Collateral Damage-Penetrating Head Injury and Orbital Injury

Deyle¹,

Exadaktylos

Kneubuehl

et al. 2011

American Journal of Forensic Medicine &Amp; Pathology

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We report a case of an accidental death or potential suicide by revolver with subsequent injury of another person. A 44-year-old man shot himself in the head while manipulating his .38 caliber special revolver in the kitchen in the presence of his wife, standing approximately 1.5 m next to him. After passing through the husband's head, the lead round-nose bullet entered the region underneath his wife's left eye. When the bullet left the man's head, it retained the energy to penetrate the soft tissue at this distance, including the skin and thin bone plates like the orbital wall. Owing to the low energy of the projectile, the entry wound was of atypical in shape and without loss of tissue. Only a small line--resembling a cut--was externally visible. The man died in the hospital from his injuries; his wife suffered visual loss of her left eye.

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Section: Discussionmentioning

confidence: 99%

Collateral Damage-Penetrating Head Injury and Orbital Injury

Deyle¹,

Exadaktylos

Kneubuehl

et al. 2011

American Journal of Forensic Medicine &Amp; Pathology

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“…In addition to their direct influence on coagulation, BDMPs and mtMPs may also bind and activate platelets as they synergize with them to disrupt the integrity of the endothelial cell junctions, thereby allowing their release into the systemic circulation (Zhao et al, 2016 ; Tian et al, 2015 ). Platelet activation has indeed been reported during the acute phase of TBI (Jacoby et al, 2001 ; Awasthi et al, 1991 ; Auer and Ott, 1979 ). Because of the anionic phospholipid exposure, activated platelets and platelet-derived microparticles serve as platforms to promote systemic coagulation and thrombosis (Warren and Vales, 1972 ).…”

Section: Microparticles and Tbi-associated Coagulopathymentioning

confidence: 88%

Cellular microparticles and pathophysiology of traumatic brain injury

et al. 2017

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Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The finding that cellular microparticles (MPs) generated by injured cells profoundly impact on pathological courses of TBI has paved the way for new diagnostic and therapeutic strategies. MPs are subcellular fragments or organelles that serve as carriers of lipids, adhesive receptors, cytokines, nucleic acids, and tissue-degrading enzymes that are unique to the parental cells. Their sub-micron sizes allow MPs to travel to areas that parental cells are unable to reach to exercise diverse biological functions. In this review, we summarize recent developments in identifying a casual role of MPs in the pathologies of TBI and suggest that MPs serve as a new class of therapeutic targets for the prevention and treatment of TBI and associated systemic complications.

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“…Grande ênfase tem sido dada à importância das lesões extraneurológicas, em especial aos distúrbios hipóxicoisquêmicos e circulatórios 25,73,75 , bem como às alterações hematológicas eventualmente associadas 6 , embora tais eventos não tenham sido passíveis de serem considerados neste trabalho.…”

Section: Discussionunclassified

Lesões craniencefálicas por projétil de arma de fogo

Freitas¹,

Bonatelli²

2018

jbnc

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Foram estudados 417 casos de ferimentos craniencefálicos por projétil de arma de fogo ocorridos em população civil, com o objetivo de determinar os fatores que influenciam a mortalidade. Foram selecionados pacientes com ferimento único, que chegaram com vida ao hospital em um período de até seis horas após o trauma e que evoluíram para o óbito após a internação ou permaneceram internados por pelo menos 48 horas. A mortalidade global foi de 63,1% – 263 casos que foram analisados separadamente. Constatou-se que mortalidade não foi influenciada, significativamente, por variáveis como idade ou sexo do paciente, causa da ocorrência, calibre do projétil, local de entrada no crânio, presença de hematoma intracraniano ou pelo tratamento instituído. Foram considerados como fatores prognósticos significativos o estado neurológico do paciente, quando de sua internação, e a trajetória do projétil – morreram 93,2% dos pacientes comatosos com ECG < 6 e 91,4% entre os que apresentaram ferimentos em que o projétil cruzou tanto o plano coronal como o sagital. Por outro lado, apenas 1,9% dos pacientes acordados sem sinais neurológicos focais e 3,8% entre os que o projétil não atravessou nenhum dos planos evoluíram para óbito. Levando-se em consideração que o prognóstico quanto à mortalidade é considerado um dos critérios mais importantes a influir sobre a decisão cirúrgica, concluiu-se que pacientes em coma profundo, com lesões bi-hemisféricas e de vários lobos cerebrais, apresentam muito mau prognóstico, com elevada taxa de mortalidade e que, provavelmente, devam ser considerados como fora de possibilidades terapêuticas.

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Coagulation changes after an experimental missile wound to the brain in the cat

Cited by 13 publications

References 22 publications

Collateral Damage-Penetrating Head Injury and Orbital Injury

Collateral Damage-Penetrating Head Injury and Orbital Injury

Cellular microparticles and pathophysiology of traumatic brain injury

Lesões craniencefálicas por projétil de arma de fogo

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