Coagulation Factor v Gene Mutation Increases the Risk of Venous Thrombosis in Behçet's Disease

Abstract

We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behçet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.

Factor V Gene (1691A and 4070G) and Prothrombin Gene 20210A Mutations in Patients with Behçet’s Disease

“…The prevalence of the FV 1691A mutation in BD varies from 0 to 38% [16][17][18][19][20][21][22][23]. In our study the frequency of heterozygous carriers of the FV 1691A mutation was 16.9% in all BD patients, 25.9% in BD patients with venous thrombosis, and 8.8% in healthy subjects.…”

“…Recently, it has been suggested that procoagulant mutations may play a role in the development of thrombotic events in BD patients. Several groups have studied the contribution of FV 1691A (Leiden) and PT 20210A mutations to thrombotic tendency in BD patients [16][17][18][19][20][21][22][23]. However, there are some controversies in this issue mainly resulting from features of the study populations.…”

“…Although the frequency of the FV 1691A mutation in BD patients with venous thrombosis was found to be significantly higher than in healthy subjects, the difference between BD patients with and without venous thrombosis did not reach a statistically significant level. Previous reports on the association between the FV 1691A mutation and venous thrombosis in BD patients are controversial, with studies favoring [17,19] or opposing [16,18,22,23] this association. Verity et al [21] reported that the FV 1691A mutation was significantly associated with ocular disease in BD patients but not with deep vein thrombosis.…”

Behçet Hastasında Non-Anevrizmatik Rekürren Pulmoner Tromboemboli

“…Moreover, the defects in fibrinolytic system have been examined, but they have not had any relation with thrombosis formation in BD (9,10). In a study, Gül et al suggested that G1691A mutation in factor V can be related to the thrombosis formation of deep veins in BD (11). But, based on the recent evidence, the thrombosis formation in BD has not been confirmed yet (8).…”

Vascular Manifestations of Behçet’s Disease

“…In the light of all these studies, it is now thought that in BD venous thrombosis develops as a result of an inflammation on the vein wall. There is a vessel wall damage and nonspecific inflammation especially in the vein adventitia [13].…”