Coagulation factor XII activity, but not an associated common genetic polymorphism (46C/T),is linked to recurrent miscarriage

Iinuma, Yoshiro; Sugiura‐Ogasawara, Mayumi; Makino, Aiko; Ozaki, Yasuhiko; Suzumori, Nobuhiro; Suzumori, Kaoru

doi:10.1016/s0015-0282(01)02989-2

Cited by 22 publications

(27 citation statements)

References 19 publications

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“…For example, lower plasma FXII activity has been demonstrated among women with IRM compared with women with uneventful past pregnancies. 8 Ogasawara et al examined various thrombophilic markers and found that plasma levels of FXII, but not protein C, protein S, and antithrombin III, are a predictor of IRM. 7 A positive association between reduced FXII activity and recurrent abortions has been documented across ethnic barriers.…”

Section: Discussionmentioning

confidence: 99%

“…The authors found no association between carriage of this polymorphism and the risk of recurrent miscarriages. 8 Among the 83 investigated women, 18% were diagnosed with antiphospholipid syndrome. Also, the genotype frequencies in this Japanese population group were markedly different from what is found among Caucasians (47% vs 10% homozygous mutant genotypes).…”

Section: Discussionmentioning

confidence: 99%

“…Our study, however, confirms the findings of Iinuma et al, falling short of determining a significant effect of the FXII C46T polymorphism on IRM. 8 Besides genetic diversity, ethnic variation also needs to be considered in an evaluation of the genetic background of IRM. Thus, we made efforts to reduce error in the interpretation of our results by only considering Middle-European Caucasian women.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the FXII C46T polymorphism has been investigated in a Japanese population of women with IRM and no association was ascertained. 8 However, the role of this FXII C46T polymorphism for IRM in the Caucasian population has not yet been evaluated.…”

Section: Introductionmentioning

confidence: 99%

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The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage

Walch

Riener

Tempfer

et al. 2005

BJOG

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Thrombophilia has been described to be involved in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the association between IRM and a C!T polymorphism at nucleotide 46 in the 5V-untranslated region of the coagulation factor XII (FXII) gene. Two hundred and twelve women with a history of IRM and 149 healthy controls were tested by a mutagenically separated polymerase chain reaction assay (MS PCR). Allele and genotype frequencies were not significantly different between the study and the control groups. Our data suggest that the FXII gene is not a candidate gene for this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage

Walch

Riener

Tempfer

et al. 2005

BJOG

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“…Foetal wastage in women with thrombotic defect results from thrombosis of early placental vessels, which peaks in the early trimester but may also occur in the 2 nd and 3 rd trimester [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] . In early weeks of pregnancy the placental vessels are smaller, undergo partial or total occlusion by thrombus formation.…”

mentioning

confidence: 99%

Role of Low Molecular Weight Heparin (LMWH) in the Treatment of Recurrent Missed Abortion

Begum

Ehsan²,

Ehsan³

et al. 2016

Bangladesh J Obstet Gynaecol

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Introduction:Recurrent pregnancy loss (RPL) is a common and frustrating obstetric problem affecting 0.5% -5% women in different population 1,2 . Approximately 15-20% of clinically recognized pregnancies are generally subjected to spontaneous abortion, mostly during first trimester 3 . Most of these abortions are early missed abortions. Missed abortion may be either embryonic (preclinical) or fetal miscarriage. Embryonic miscarriage is defined as an embryo with crown rump length of more than or equal to 5cm without cardiac activity, fetal miscarriage is defined as a fetus of 7-20 weeks size with negative cardiac activity 4 .Genetic factors including chromosomal disorders, single gene defects, and multifactorial factors account for 3.5-5% of the causes of recurrent missed abortion 5 . There is a big volume of literature describing that cytogenetic abnormality is detected in 31% of early missed abortion 6,7 . Other studies showed that foetal chromosomal abnormalities account for about 50% of first trimester and near 30% of second trimester pregnancy losses 8,9 . Studies revealed that maternal insertional translocation associated with recurrent missed abortion 10-15 .

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New Frontiers in RPL Research and Treatment

Bashiri

Shemesh

Porgador

et al. 2016

Recurrent Pregnancy Loss

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Coagulation factor XII activity, but not an associated common genetic polymorphism (46C/T),is linked to recurrent miscarriage

Cited by 22 publications

References 19 publications

The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage

The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage

Role of Low Molecular Weight Heparin (LMWH) in the Treatment of Recurrent Missed Abortion

New Frontiers in RPL Research and Treatment

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