Coagulation Factors and Recurrence of Ischemic and Bleeding Adverse Events in Patients with Acute Coronary Syndromes

Campo, Gianluca; Pavasini, Rita; Pollina, Alberto; Tebaldi, Matteo; Ferrari, Roberto

doi:10.1016/j.thromres.2013.06.007

Cited by 24 publications

(27 citation statements)

References 59 publications

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“…New anticoagulant drugs, which show less side effects and a better tolerability, recently are used widely. Therefore, their selected use in patients with increased levels of coagulation factors, including FVII, may not only improve the clinical outcome after MI but also prevent the onset of MI …”

Section: Introductionmentioning

confidence: 99%

Factor VII and incidence of myocardial infarction in a Japanese population: The Jichi Medical School Cohort Study

Shiraishi¹,

Ishikawa

Kario

et al. 2017

Clinical Laboratory Analysis

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Section: Introductionmentioning

confidence: 99%

Factor VII and incidence of myocardial infarction in a Japanese population: The Jichi Medical School Cohort Study

Shiraishi¹,

Ishikawa

Kario

et al. 2017

Clinical Laboratory Analysis

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“…Increased fibrinogen plasmatic levels are directly related with the risk of ACS [8]. It takes part in the atherosclerosis process inducing plaque growth, stimulating adhesion of platelets and white blood cells to the vessels wall cells, endothelial dysfunction, and promoting muscle cell proliferation and migration [9,10]. Plasma fibrinogen levels have been found to be higher in patients with ACS compared to those of patients with stable coronary artery disease or healthy controls, and higher plasma fibrinogen levels may be predictors of poor long-term prognosis [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The association of plasma fibrinogen with the extent and complexity of coronary lesions in patients with acute coronary syndrome

Kurtul¹,

Yarlıoğlueş

Murat

et al. 2016

Kardiol Pol

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A b s t r a c tBackground: High Syntax score (SXscore) is associated with more serious disease and worse prognosis in patients with acute coronary syndrome (ACS). Plasma fibrinogen levels are associated with poor cardiovascular outcomes. Aim:To investigate the relation of admission fibrinogen levels with intermediate-high SXscore in patients with ACS. Methods:A total of 752 patients (61.6 ± 12.8 years, 67.3% men) with ACS, who underwent urgent coronary angiography (CAG) were enrolled. Laboratory data including fibrinogen and high sensitivity C-reactive protein were obtained before CAG. Syntax scores of all patients were calculated from baseline CAG. The patients were divided into two groups: low SXscore (≤ 22) and intermediate-high SXscore (≥ 23).Results: Admission fibrinogen levels were significantly higher in the SXscore ≥ 23 group when compared with the SXscore ≤ 22 group (median 492 mg/dL, interquartile range 428-581 mg/dL vs. median 370 mg/dL, interquartile range 309-428 mg/dL, respectively; p < 0.001). In multivariate analysis, the independent predictors of intermediate-high SXscore were fibrinogen (OR 1.008, 95% CI 1.005-1.010, p < 0.001), left ventricular ejection fraction (OR 0.935, p < 0.001), and age (OR 1.029, p = 0.041). A level of fibrinogen > 417 mg/dL had an 80.0% sensitivity and 71.3% specificity in predicting intermediate-high SXscore. Conclusions:Increased fibrinogen levels are independently associated with intermediate-high SXscore in patients with ACS.

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“…In fish, the complement system appears to be fully equipped with the three C3-activation pathways and the cytolytic pathway, showing many of the typical effector activities, such as target cell killing, opsonization, and anaphylatoxic leukocyte stimulation (Nakao et al, 2011). FI to FXIII play important roles in tissue coagulation, fibrinolysis, and anticoagulation (Campo et al, 2013;Hoppe, 2014). C5 is a key factor linking the complement system and coagulation cascade (Ehrnthaller et al, 2011;Kolev et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Characterization of grass carp spleen transcriptome during GCRV infection

Zhong

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The aim of the study was to investigate the grass carp hemorrhagic infection pathway and its key-related genes. Grass carp reovirus (GCRV) might cause hemorrhagic disease in grass carps. Healthy grass carp fingerlings (N = 60) were divided into control and infected groups. Fish in the control group were intraperitoneally (ip) injected with 0.6% fish physiological saline; the infected group received 5,000,000 50% tissue culture infective doses of GCRV 873 standard strain, a double-stranded RNA (dsRNA) virus strain, ip, in 0.5 mL. Illumina HiSeq TM 2000 was used for transcriptome sequencing, and real-time polymerase chain reaction (PCR) used to detect complement factors II (C2), III (C3), and V (C5); profibrinolysin (PLG); and coagulation factor II (F2) expression. A total of 2,722,223 reads were detected in the control group, and 2,751,111 in the infected group. Among 11,023 unigenes obtained after transcriptome assembly, 10,021 unigenes were significantly differentially expressed. Gene ontology and KEGG analysis, a collection of databases dealing with genomes and biological pathways, were performed to classify unigenes into functional categories, to understand gene function and identify regulatory pathways. Real-time PCR analysis showed that C2, C3, C5, PLG, and F2 expression levels were down-regulated, confirming results of pathway-enrichment analysis. This is the first application of highthroughput sequencing technology to investigate the in vivo effects of GCRV, on genes and pathways involved in the immune response to infection in grass carp.

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Coagulation Factors and Recurrence of Ischemic and Bleeding Adverse Events in Patients with Acute Coronary Syndromes

Cited by 24 publications

References 59 publications

Factor VII and incidence of myocardial infarction in a Japanese population: The Jichi Medical School Cohort Study

Factor VII and incidence of myocardial infarction in a Japanese population: The Jichi Medical School Cohort Study

The association of plasma fibrinogen with the extent and complexity of coronary lesions in patients with acute coronary syndrome

Characterization of grass carp spleen transcriptome during GCRV infection

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