Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects

Abstract

Background: Obesity is a major risk factor for developing cardiovascular disorders due to increased platelets count and platelets activation. Objective: The aim of this study was to measure the influence of weight loss on the coagulation and fibrinolysis parameters among obese patients. Material and Methods: One hundred obese subjects of both genders (mean age 46.72± 3.13 year) selected from the Internal Medicine Department at King Abdul Aziz University Teaching Hospital, their body mass index (BMI) ranged from 32 to 36 Kg/m 2 . Participants enrolled randomly into two study groups; the first group (A) received aerobic exercises and diet regimen for three months, while the second group (B) received no exercise training or diet regimen for three months. Results: Mean values of von Willbrand factor antigen (vWF-Ag), fibrinogen, plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and plasminogen activator inhibitor-1 activity (PAI-1:Ac), tumor necrotic factor-alpha (TNF-α), Interleukin -6 (IL-6) and body mass index (BMI), while the mean values of partial thromboplastin time (PTT), prothrombin time (PT), tissue plasminogen activator antigen (tPA:Ag) and tissue plasminogen activator activity (tPA:Ac) increased significantly after 3 months in group (A) as a result of weight reduction program. However, the mean values of all investigated parameters of group (B) had no significant changes. Moreover, comparison between both groups had statistical significant differences in all investigated parameters at the end of the study (P<.05). Conclusion: weight reduction program modulates systemic inflammation, fibrinolytic and coagulation of obese subjects.

The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

“…The findings have indicated that regular aerobic exercise significantly regulates homeostasis by reducing precoagulation factors and increasing anticoagulation factors 44 , 45 . Possible related mechanisms are that aerobic exercise enhances vascular endothelial integrity, vascular permeability, and the release of vasodilators [46] , such as nitric oxide, which induces the release of tissue plasminogen activator (tPA) from endothelial cells 46 , 47 and suppresses plasminogen activator inhibitor type 1 (PAI-1) production by vessels and platelets [46] . An inverse correlation has been shown between physical activity and TF (factor VIII) 48 , 49 , and factor VII decreases in sedentary men following three months of aerobic exercise training [48] .…”

Effects of dietary-based weight loss interventions on biomarkers of endothelial function: a systematic review and meta-analysis

“…The duration of the interventions ranged from 3 weeks to 52 weeks (Table 1). From the 37 studies, 27 looked at the impact of caloric restriction on obese patients [26,27,29,31,, 4 in patients with type 2 diabetes mellitus (T2DM) [40,41,45,53], 3 in patients with metabolic syndrome [46,48,59] and 1 in postmenopausal women [44]. Multiple variations of calorie restriction diets were used in the included papers ranging from very low-calorie diets (VLCD) to the Mediterranean diet and lowfat diets.…”