Coagulation markers in patients with coronary artery disease

Marynenko, Tetiana; Halenova, Tetiana; Raksha, Nataliia; Vovk, Tetiana; Tyravska, Yuliya; Savchuk, О.; Остапченко, Л. И.

doi:10.4081/jbr.2022.10259

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Patients with kidney disease are more often diagnosed with peripheral atherosclerosis than equivalents without renal dysfunction [ 29 , 30 , 31 ]. Chronic kidney disease (CKD) and atherosclerosis share the same risk factors (smoking, age, sex, comorbidities such as hypertension, diabetes, and hyperlipidemia) inducing vascular damage.…”

Section: Endothelial Disfunction In Chronic Kidney Disease and The Ri...mentioning

confidence: 99%

The Role of the Coagulation System in Peripheral Arterial Disease: Interactions with the Arterial Wall and Its Vascular Microenvironment and Implications for Rational Therapies

Miceli

Basso

Rizzo

et al. 2022

IJMS

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Peripheral artery disease (PAD) is a clinical manifestation of atherosclerotic disease with a large-scale impact on the economy and global health. Despite the role played by platelets in the process of atherogenesis being well recognized, evidence has been increasing on the contribution of the coagulation system to the atherosclerosis formation and PAD development, with important repercussions for the therapeutic approach. Histopathological analysis and some clinical studies conducted on atherosclerotic plaques testify to the existence of different types of plaques. Likely, the role of coagulation in each specific type of plaque can be an important determinant in the histopathological composition of atherosclerosis and in its future stability. In this review, we analyze the molecular contribution of inflammation and the coagulation system on PAD pathogenesis, focusing on molecular similarities and differences between atherogenesis in PAD and coronary artery disease (CAD) and discussing the possible implications for current therapeutic strategies and future perspectives accounting for molecular inflammatory and coagulation targets. Understanding the role of cross-talking between coagulation and inflammation in atherosclerosis genesis and progression could help in choosing the right patients for future dual pathway inhibition strategies, where an antiplatelet agent is combined with an anticoagulant, whose role, despite pathophysiological premises and trials’ results, is still under debate.

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Section: Endothelial Disfunction In Chronic Kidney Disease and The Ri...mentioning

confidence: 99%

The Role of the Coagulation System in Peripheral Arterial Disease: Interactions with the Arterial Wall and Its Vascular Microenvironment and Implications for Rational Therapies

Miceli

Basso

Rizzo

et al. 2022

IJMS

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Characteristics of Products of Fibrinogen Origin in the Presence of Anti- SARS-CoV-2 IgG in the Bloodstream

Rachkovska

Krenytska

Karbovskyy

et al. 2023

RRCT

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Background: The hemostasis system has been extensively investigated in patients in the acute phase of coronavirus disease 2019 (COVID-19). In contrast, the post-COVID syndrome is a poorly known entity, and there is a lack of information on the mechanisms underlying the hemostasis abnormalities in the post-COVID period. Aim: To analyze the potential changes in the parameters of the hemostasis system in the post-COVID period in the plasma of donors with different titers of anti-SARS-CoV-2 IgG. Methods: The plasma from 160 donors who had recovered from COVID infection was used in the study. Based on the results of the Abbott SARS-CoV-2 IgG serological assay, all donors were divided into several groups: 5 ± 3 (n=20); 55 ± 5 (n=20); 65 ± 5 (n=20); 75 ± 5 (n=20); 85 ± 5 (n=20); 95 ± 5 (n=20); 125 ± 5 (n=20); 175 ± 5 (n=20) Index (S/C). A total of 20 healthy individuals without anti-SARS-CoV-2 IgG constituted the control group. Key laboratory parameters, such as fibrinogen concentrations, soluble fibrin monomer complex (SFMCs), and D-dimer, were investigated. In addition, the qualitative composition of the fraction of SFMCs was analyzed. Results: The slight increase in the concentration of fibrinogen, SFMCs, and D-dimers in some donor groups have been found, which could cause the development of hemostasis disorders. In the fraction of SFMCs, the increase in the number of protein fragments with a molecular weight of less than 250 kDa and an increase in the level of proteins with a molecular weight of more than 270 kDa was revealed. Conclusion: The obtained results indicated the relationship between the changes in the parameters of the hemostasis system and the titers of anti-SARS-CoV-2 IgG in donors in the post-COVID period. It can be assumed that donors with higher titers of anti-SARS-CoV-2 IgG (>55 ± 5 Index (S/C)) are more prone to hemostasis abnormalities in the post-COVID period since a pronounced imbalance in the levels of SFMCs and D-dimer characterizes them. The appearance of protein fragments of different molecular weights in the fraction of SFMC points to uncontrolled activation of biochemical processes involving molecules of fibrinogenic origin. Additional studies are required to elucidate the role of anti-SARS-CoV-2 IgG in the post-COVID period.

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Optimization of surgical treatment for lower extremities and infrarenal aorta atherosclerosis

Shaprynskyi,

Shaprynskyi

2023

ЕМ

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Background. Atherosclerosis of the infrarenal aorta and lower extremities is a disease caused by hyperlipidemia, arterial hypertension, tobacco smoking, hyperglycemia, metabolic disorders, and physical inactivity The research aims to optimize surgical treatment and its effectiveness in patients with occlusions of the distal aorta and lower extremities. Materials and methods. For patients from the main group, diagnostic and prognostic tactics were used, addressing 18 major risk factors, which allowed to predict the presence or absence of risk for recurrent postoperative thrombosis, which could end in surgery to eliminate thrombosis, amputation, or death. For patients with severe calcification of the arterial wall, an improved surgical technique was used to reduce the rate of significant complications. Results. The results of treatment were analyzed in 98 patients with occlusive stenotic lesions of the main arteries as a consequence of obliterating atherosclerosis who were operated by the open method. Conclusions. The research outcomes indicated the importance of determining individual risk before surgery, as this allowed for planning the scope of the operation and choose appropriate access. These measures reduced the rate of postoperative complications. In addition, it became possible to gather patients into a group of standard treatment and those who need special monitoring, which improved early postoperative outcomes in the future such as early postoperative mortality and amputation rates. The study also analyzed the importance of active tactics for treating postoperative complications which reduce the risk of complications that lead to reoperation or amputation.

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Coagulation markers in patients with coronary artery disease

Cited by 4 publications

References 26 publications

The Role of the Coagulation System in Peripheral Arterial Disease: Interactions with the Arterial Wall and Its Vascular Microenvironment and Implications for Rational Therapies

The Role of the Coagulation System in Peripheral Arterial Disease: Interactions with the Arterial Wall and Its Vascular Microenvironment and Implications for Rational Therapies

Characteristics of Products of Fibrinogen Origin in the Presence of Anti- SARS-CoV-2 IgG in the Bloodstream

Optimization of surgical treatment for lower extremities and infrarenal aorta atherosclerosis

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