Coagulopathy and clotting disorders

Senzolo, Marco; Burroughs, Andrew K.

doi:10.1002/9781118412640.ch22

Cited by 2 publications

(2 citation statements)

References 131 publications

(130 reference statements)

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“…The relation between liver diseases and hemostasis is believed to be complex; some patients with advanced liver disease can experience severe bleeding whilst others may even suffer thrombotic complications because of reduced plasma levels of pro-coagulative and anticoagulative clotting factors synthesized by the liver [ 1 , 2 ]. Patients with liver cirrhosis may develop a serious coagulopathy whose origin is multifactorial, and one of them is accelerated hyperfibrinolysis.…”

Section: Introductionmentioning

confidence: 99%

Serum and ascitic D-dimer in cirrhotic patients with spontaneous bacterial peritonitis

Gohary

Elyamany

Mikhael

et al. 2021

ceh

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Section: Introductionmentioning

confidence: 99%

Serum and ascitic D-dimer in cirrhotic patients with spontaneous bacterial peritonitis

Gohary

Elyamany

Mikhael

et al. 2021

ceh

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“…It is thought that there is a complex relationship between liver diseases and hemostasis; certain cases with advanced hepatic disorder may develop extensive blood loss, while others could even experience thrombotic adverse events due to reduced plasma values of clotting factors produced by the liver [1,2] . A significant coagulopathy that can affect patients with liver cirrhosis might have many different causes, one of which is rapid hyperfibrinolysis.…”

Section: Introductionmentioning

confidence: 99%

Serum and Ascitic D-Dimer in Cirrhotic Patients with Spontaneous Bacterial Peritonitis in Minia University Hospital

2023

The Egyptian Journal of Hospital Medicine

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Background: The D-dimer (DD) test can detect fibrinolysis with good specificity. Its irregularity is a result of the coagulation and fibrinolysis systems being overactive in vivo. Since disrupted hemostasis is linked to chronic liver illness, it's probable that clot lysis as well as coagulation problems are also present. Estimating DD might shed light on potential disruptions in the fibrinolytic process. Objective: We aimed to determine the connection between ascites and the hyper fibrinolytic condition in hepatic cirrhosis. We evaluated serum DD in cirrhotic cases with and without ascites. We also examined how spontaneous bacterial peritonitis (SBP) affected the DD content in serum and ascitic fluid (AF). Patients and methods: This prospective study was conducted on 60 patients from the Department of Internal Medicine in Minia University Hospital including patients hospitalized due to decompensated liver cirrhosis and ascites. First group included fifteen cases with hepatic cirrhosis and no ascites. Second group included fifteen cirrhotic cases with ascites. Third group included fifteen cirrhotic cases with ascites and SBP. Fourth group (Control group) included fifteen matched healthy individuals with no evidence of hepatic disorder. Results: There was a diagnostic performance of serum DD in diagnosing of SBP in cutoff point of serum d dimer > 491.5 ng/ml, and ascitic DD in a cutoff point of ascitic d dimer > 380.5 ng/ml predicting cirrhotic ascitic cases with SBP. Conclusions: Patients with SBP showed a substantial link between serum DD and AF DD, while patients with cirrhotic ascites without bacterial infection demonstrated no significant correlation. When used to diagnose SBP in cases with hepatic cirrhosis, DD performed well.

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Coagulopathy and clotting disorders

Cited by 2 publications

References 131 publications

Serum and ascitic D-dimer in cirrhotic patients with spontaneous bacterial peritonitis

Serum and ascitic D-dimer in cirrhotic patients with spontaneous bacterial peritonitis

Serum and Ascitic D-Dimer in Cirrhotic Patients with Spontaneous Bacterial Peritonitis in Minia University Hospital

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