Coarctation of the thoracic aorta masquerading as bilateral aorto-iliac stenosis

Thani, Khalid Bin; Kaushal, Kalpana; Barnard, Denise; Jg, Copeland; Prasad, Anand

doi:10.1016/j.jccase.2011.08.002

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…In circulatory conditions such as coarctation of the aorta (CoA) and peripheral artery disease (PAD), blood flow from the heart to the extremities is reduced by a narrowing in the aorta or peripheral arteries, respectively. One standard non-invasive test to screen and monitor patients with CoA and PAD is the ankle-brachial index (ABI), measured as the ratio of the blood pressure in the ankles and arms [13, 53, 50, 1]. Systemic arterial flow simulations that compute the ABI have the potential to improve the ability of clinicians to identify, treat, and monitor at-risk patients with circulatory conditions such as CoA and PAD.…”

Section: Introductionmentioning

confidence: 99%

Computing the ankle-brachial index with parallel computational fluid dynamics

Gounley¹,

Draeger²,

Oppelstrup³

et al. 2019

Journal of Biomechanics

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The ankle-brachial index (ABI), a ratio of arterial blood pressure in the ankles and upper arms, is used to diagnose and monitor cirulatory conditions such as coarctation of the aorta and peripheral artery disease. Computational simulations of the ABI can potentially determine the parameters that produce an ABI indicative of ischemia or other abnormalities in blood flow. However, 0-and 1-D computational methods are limited in describing a 3-D patient-derived geometry. Thus, we present a massively parallel framework for computational fluid dynamics (CFD) simulations in the full arterial system. Using the lattice Boltzmann method to solve the Navier-Stokes equations, we employ highly parallelized and scalable methods to generate the simulation domain and efficiently distribute the computational load among processors. For the first time, we compute an ABI with 3-D CFD. In this proof-of-concept study, we investigate the dependence of ABI on the presence of stenoses, or narrowed regions of the arteries, by directly modifying the arterial geometry. As a result, our framework enables the computation a hemodynamic factor characterizing flow at the scale of the full arterial system, in a manner that is extensible to patient-specific imaging data and holds potential for treatment planning.

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Section: Introductionmentioning

confidence: 99%

Computing the ankle-brachial index with parallel computational fluid dynamics

Gounley¹,

Draeger²,

Oppelstrup³

et al. 2019

Journal of Biomechanics

View full text Add to dashboard Cite

show abstract

“…2 Usualmente, el diagnóstico se realiza durante la infancia, sin embargo, su diagnóstico puede ser tardío. 3 La CoA no tratada tiene un pobre pronóstico en la mayoría de los pacientes, asociando morbilidades como hipertensión arterial, hipertrofia ventricular izquierda, valvulopatía mitral, estenosis subaórtica, muerte prematura, falla cardíaca, eventos cerebro-vasculares y enfermedad arterial coronaria prematura. 4 El tratamiento usual de esta condición fue siempre la cirugía, al principio mediante la resección del segmento estenótico y la reanastaomosis aórtica, 5 y posteriormente, utilizando colgajos arteriales o parches biológicos o sintéticos, para aumentar el lumen.…”

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Reparación endovascular de coartación de aorta con parada cardíaca inducida con adenosina

Rivera-Chavarría

Abarca-Brenes

Brenes-Gutiérrez

et al. 2020

AMC

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La coartación de aorta es un estrechamiento congénito de la luz aórtica que, generalmente, afecta la porción torácica distal a la emergencia de la arteria subclavia izquierda. Esta condición es de gran importancia, pues predispone al desarrollo de patologías cardiovasculares a edades tempranas, lo que se traduce en una alta morbimortalidad. Se reporta el primer caso en Costa Rica, de reparación endovascular de una coartación de aorta, mediante la colocación de un stent recubierto, con parada cardiaca inducida con adenosina. La paciente toleró el procedimiento bien y el gradiente postintervención fue menor de 5 mmHg. Su presión arterial sistémica es 100/60mmHg y no tiene limitaciones o sintomatología.

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Coarctation of the thoracic aorta masquerading as bilateral aorto-iliac stenosis

Abstract: We present a case with coarctation of the aorta (CoA) with lifestyle limiting claudication and lower extremity weakness, successfully treated with surgical correction. The presented case discusses the diagnostic challenges associated with identifying CoA in patients with claudication.

Cited by 2 publications

References 19 publications

Computing the ankle-brachial index with parallel computational fluid dynamics

Computing the ankle-brachial index with parallel computational fluid dynamics

Reparación endovascular de coartación de aorta con parada cardíaca inducida con adenosina

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