In the present Letter, first-of-its-kind computer simulations predicting plasma profiles for modern optimized stellarators -while self-consistently retaining neoclassical transport, turbulent transport with 3D effects, and external physical sources -are presented. These simulations exploit a newly developed coupling framework involving the global gyrokinetic turbulence code GENE-3D, the neoclassical transport code KNOSOS, and the 1D transport solver TANGO. This framework is used to analyze the recently observed degradation of energy confinement in electron-heated plasmas in the Wendelstein 7-X stellarator, where the central ion temperature was "clamped" to Ti ≈ 1.5 keV regardless of the external heating power. By performing first-principles based simulations, the key mechanism leading to this effect is identified and guidelines for improving the plasma performance in future experimental campaigns are put forth. This work paves the way towards the use of highfidelity models for the development of the next generation of stellarators, in which neoclassical and turbulent transport are optimized simultaneously.