2020
DOI: 10.1101/2020.09.23.309138
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Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential

Abstract: Identification of the metastatic potential represents one of the most important tasks for molecular imaging of cancer. While molecular imaging of metastases has witnessed substantial progress as an area of clinical inquiry, determining precisely what differentiates the metastatic phenotype has proven to be more elusive underscoring the need to marry emerging imaging techniques with tumor biology. In this study, we utilize both the morphological and molecular information provided by 3D optical diffraction tomog… Show more

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“…[ 46 ] Furthermore, LM231 cells displayed a larger area and higher cell mass as compared to P231 cells. [ 47 ] Based on these recent findings, we sought to investigate if P231, LM231, and BoM cells would interact differently with the hydrophobic–hydrophilic nanowire substrate.…”
Section: Resultsmentioning
confidence: 99%
“…[ 46 ] Furthermore, LM231 cells displayed a larger area and higher cell mass as compared to P231 cells. [ 47 ] Based on these recent findings, we sought to investigate if P231, LM231, and BoM cells would interact differently with the hydrophobic–hydrophilic nanowire substrate.…”
Section: Resultsmentioning
confidence: 99%