A tropical cyclone is a significant natural phenomenon that results in substantial socio-economic and environmental damage. These catastrophes impact millions of people every year, with those who live close to coastal areas being particularly affected. With a few coastal cities with large population densities, Tamil Nadu’s coast is the third-most cyclone-prone state in India. This study involves the generation of a cyclone risk map by utilizing four distinct components: hazards, exposure, vulnerability, and mitigation. The study employed a Geographical Information System (GIS) and an Analytical Hierarchical Process (AHP) technique to compute an integrated risk index considering 16 spatial variables. The study was validated by the devastating cyclone GAJA in 2018. The resulting risk assessment shows the cyclone risk is higher in zones 1 and 2 in the study area and emphasizes the variations in mitigation impact on cyclone risk in zones 4 and 5. The risk maps demonstrate that low-lying areas near the coast, comprising about 3%, are perceived as having the adaptive capacity for disaster mitigation and are at heightened risk from cyclones regarding population and assets. The present study can offer valuable guidance for enhancing natural hazard preparedness and mitigation measures in the coastal region of Tamil Nadu.