Coating biodegradable magnesium alloys with electrospun poly-L-lactic acid-åkermanite-doxycycline nanofibers for enhanced biocompatibility, antibacterial activity, and corrosion resistance

Bakhsheshi-Rad, H.R.; Akbari, Mohsen; Ismail, Ahmad Fauzi; Aziz, Madzlan; Hadisi, Zhina; Pagan, Erik; Daroonparvar, Mohammadreza; Chen, Daniel

doi:10.1016/j.surfcoat.2019.124898

Cited by 84 publications

(49 citation statements)

References 51 publications

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“…In a further step, the PLLA-AKT fibres were loaded with an antibiotic (Doxycycline). The resulting coating considerably increased antibacterial response compared to fibres with no doxycycline and maintained a good biocompatibility with low concentrations of doxycycline (5 wt%) [90]. This study is an illustrating example of how electrospun nanofibres can be enriched with active compounds to modulate corrosion processes and microorganism activity.…”

Section: Release Of Active Compoundsmentioning

confidence: 81%

“…Corrosion processes can be influenced by the metabolic activity of some microorganisms [80,81]. This type of corrosion, termed microbial induced corrosion (MIC), or biocorrosion, affects most of the systems exposed to a biological environment, including marine structures [82,83], offshore oil and gas industries [84,85], water distillation and other separation processes [86][87][88] and biomedical devices [89][90][91], where the proliferation of microorganisms can provoke implant-associated infections [92,93]. From the US $2.2 trillion of annual cost of corrosion worldwide estimated by the World Corrosion Organization [94], the economic burden imputed to biocorrosion could be getting on for 20%, that is $440 billion yearly [95][96][97][98].…”

Section: Emerging Trends Of Electrospun Coatings: the Case Of Biocorrmentioning

confidence: 99%

“…The shell of the fibres will serve to protect and control the release. Alternatively, nanoparticles can be used to carry active compounds [90]. Widely used in the biomedical sector for tissue engineering scaffolds fabrication, electrospun fibres have been successfully used as a protective barrier to enhance the biocompatibility of magnesium alloys whilst improving the corrosion resistance.…”

Section: Release Of Active Compoundsmentioning

confidence: 99%

“…The good mechanical resistance-to-weight ratio, mechanical properties close to human bone, good biocompatibility and biodegradation properties, which permits avoiding surgeries for removal, makes Mg alloys good candidates for medical prostheses [112]. Nevertheless, their in-vivo corrosion rate and degradation, which causes hydrogen release and alkalization of the pH, are hard to predict and are up to this time a challenge [90,113]. Surface modifications and coatings can often be needed [114].…”

Section: Release Of Active Compoundsmentioning

confidence: 99%

“…Aluminium alloy (AA2024-T3) Electrochemical Impedance spectroscopy (EIS) [79] PAA/β-CD/TiO 2 NPs and CVD-silanization process Aluminium alloy (AA6061-T6) Tafel polarization curves and cyclic potentiodynamic polarization curves [53] Sputtering Ta 2 O 5 and PCL/MgO-Ag As-cast Mg-Ca-Zn specimen Tafel polarization curves and Electrochemical Impedance Spectroscopy (EIS) [115] Gelatin As-cast Mg-Ca-Zn specimen Metal ion concentration and pH monitoring [89] PLLA-AKT-DOXY As-cast Mg-Ca specimen Tafel polarization curves, Electrochemical Impedance Spectroscopy (EIS) and hydrogen evolution [90] PCL/ZnO Magnesium alloy (AZ31) Tafel polarization curves and Electrochemical Impedance Spectroscopy (EIS) [116]…”

Section: And Ceomentioning

confidence: 99%

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Electrospinning: A Powerful Tool to Improve the Corrosion Resistance of Metallic Surfaces Using Nanofibrous Coatings

Rivero

Redin

Rodríguez

2020

Metals

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The use of surface engineering techniques to tune-up the composition of nanostructured thin-films for developing functional coatings with advanced properties is a hot topic within the scientific community. The control of the coating structure at the nanoscale level allows improving the intrinsic properties of the surface compared to bulk materials. A nanodeposition technique with increasing popularity in the field of nanotechnology is electrospinning. This technique permits the fabrication of long and continuous fibres on the micro-nano scale. The good control over fibre morphology combined with its simplicity, cost-effectiveness, easy exploitability and scalability make electrospinning a very interesting tool for technological applications. This review is focused on the use of the electrospinning technique to protect metallic surfaces against corrosion. Polymeric precursors, from natural or biodegradable to synthetic polymers and copolymers can be electrospun with an adequate control of the operational deposition parameters (applied voltage, flow rate, distance tip to collector) and the intrinsic properties of the polymeric precursor (concentration, viscosity, solvent). The electrospun fibres can be used as an efficient alternative to encapsulate corrosion inhibitors of different nature (inorganic or organic) as well as self-healing agents which can be released to reduce the corrosion rate in the metallic surfaces.

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Section: Release Of Active Compoundsmentioning

confidence: 81%

Section: Emerging Trends Of Electrospun Coatings: the Case Of Biocorrmentioning

confidence: 99%

Section: Release Of Active Compoundsmentioning

confidence: 99%

Section: Release Of Active Compoundsmentioning

confidence: 99%

Section: And Ceomentioning

confidence: 99%

See 3 more Smart Citations

Electrospinning: A Powerful Tool to Improve the Corrosion Resistance of Metallic Surfaces Using Nanofibrous Coatings

Rivero

Redin

Rodríguez

2020

Metals

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Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

et al. 2022

Self Cite

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Since ancient times, wound dressings have experienced many significant improvements. Evolution began using natural materials to merely cover wounds and advanced to used innovative techniques that can be customized to perform different impressive functions. Recent wound dressings, which are made of electrospun polymers, contain different active compounds, such as antimicrobial agents, that aid in wound healing and prevent dehydration and infection. The mentioned issues may influence the healing process, leading even to serious health risks for the patients. As a result, scientists are now working on novel wound bandages with improved antimicrobial properties. Electrospun polymeric nanofibers, because of their structural similarities to normal skin's extracellular matrix (ECM), bactericidal activity, and appropriateness to distribute bioactive molecules to the wound location, are regarded as good resources for enhancing skin regeneration and controlling wound infection. Herein, the latest findings on approaches for producing antimicrobial polymeric nanofibers using electrospinning and related processes are discussed. Recent advances in antibacterial biopolymeric nanofibers incorporating antimicrobial nanoparticles (silver, zinc oxide, copper oxide, etc.) are discussed. This review paper may raise significant issues, encourage additional research, and offer important insight into the potential area of antibacterial polymeric fibers.

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Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration

Crawford

Wyatt

Bryers

et al. 2021

Adv Healthcare Materials

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The word "biocompatibility," is inconsistent with the observations of healing for so-called biocompatible biomaterials. The vast majority of the millions of medical implants in humans today, presumably "biocompatible," are walled off by a dense, avascular, crosslinked collagen capsule, hardly suggestive of life or compatibility. In contrast, one is now seeing examples of implant biomaterials that lead to a vascularized reconstruction of localized tissue, a biological reaction different from traditional biocompatible materials that generate a foreign body capsule. Both the encapsulated biomaterials and the reconstructive biomaterials qualify as "biocompatible" by present day measurements of biocompatibility. Yet, this new generation of materials would seem to heal "compatibly" with the living organism, where older biomaterials are isolated from the living organism by the dense capsule. This review/perspective article will explore this biocompatibility etymological conundrum by reviewing the history of the concepts around biocompatibility, today's standard methods for assessing biocompatibility, a contemporary view of the foreign body reaction and finally, a compendium of new biomaterials that heal without the foreign body capsule. A new definition of biocompatibility is offered here to address advances in biomaterials design leading to biomaterials that heal into the body in a facile manner.

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Coating biodegradable magnesium alloys with electrospun poly-L-lactic acid-åkermanite-doxycycline nanofibers for enhanced biocompatibility, antibacterial activity, and corrosion resistance

Cited by 84 publications

References 51 publications

Electrospinning: A Powerful Tool to Improve the Corrosion Resistance of Metallic Surfaces Using Nanofibrous Coatings

Electrospinning: A Powerful Tool to Improve the Corrosion Resistance of Metallic Surfaces Using Nanofibrous Coatings

Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration

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