Coating biomimetic nanoparticles with chimeric antigen receptor T cell-membrane provides high specificity for hepatocellular carcinoma photothermal therapy treatment

Ma, Weijie; Zhu, Delan; Liu, Jinghua; Chen, Xi; Xie, Wei; Jiang, Xiang; Wu, Long; Wang, Ganggang; Xiao, Yusha; Liu, Zhisu; Wang, Xinghuan; Li, Andrew; Shao, Dan; Dong, Wen‐Fei; Liu, Wei; Yuan, Yufeng

doi:10.7150/thno.40291

Cited by 162 publications

(131 citation statements)

References 51 publications

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“…Using these bioinspired strategies, researchers have successfully endowed the NPs with many desirable features. In recent years, a variety of cells other than red blood cells (RBCs) [41], including cancer cells [42][43][44], macrophages [31,45], CAR-T cell membrane [46], and stem cells [47,48], have been used to obtain membrane materials. Specialized NP platforms have been developed with tailored functionalities by coating the NP core with hybrid membranes, formed by fusing natural membranes from different types of cells.…”

Section: Introductionmentioning

confidence: 99%

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

et al. 2020

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Cell membrane-covered drug-delivery nanoplatforms have been garnering attention because of their enhanced biointerfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specialized cells or hybrid membranes that combine the capacities of different types of cell membranes. Here, hybrid membrane-coated doxorubicin (Dox)-loaded poly(lacticco-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated by fusing membrane components derived from RAW264.7(RAW) and 4T1 cells (4T1). These NPs were used to treat lung metastases originating from breast cancer. This study indicates that the coupling of NPs with a hybrid membrane derived from macrophage and cancer cells has several advantages, such as the tendency to accumulate at sites of inflammation, ability to target specific metastasis, homogenous tumor targeting abilities in vitro, and markedly enhanced multi-target capability in a lung metastasis model in vivo. The DPLGA@[RAW-4T1] NPs exhibited excellent chemotherapeutic potential with approximately 88.9% anti-metastasis efficacy following treatment of breast cancer-derived lung metastases. These NPs were robust and displayed the multi-targeting abilities of hybrid membranes. This study provides a promising biomimetic nanoplatform for effective treatment of breast cancer metastasis.

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Section: Introductionmentioning

confidence: 99%

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

et al. 2020

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“…Because of these complications, decreasing oxygen consumption is regarded as a better approach. Known in vivo respiratory depressants such as atovaquone (ATO) ( Pernicova and Korbonits, 2014 ), nitric oxide (NO) ( Morales and Morris, 2015 ), dichloroacetic acid ( Song X. et al, 2016 ) and metformin (MET) ( Ma et al, 2020 ) can inhibit tumor oxygen consumption, resulting in increased sensitivity of the cells to hypoxia-resistant treatments. Importantly, compared with other respiratory depressants, the FDA-approved metformin, as a commonly used drug in treating type II diabetes mellitus, has been approved by the FDA owing to its hydrophilicty and extremely low levels of toxic side effects.…”

Section: Introductionmentioning

confidence: 99%

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Huang

Chang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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The restriction of a tumor’s energy supply is proven to be an effective means of treatment. Glucose oxidase (GOx), an enzyme that catalyzes the conversion of glucose to glucolactone, producing oxygen and hydrogen peroxide in the process, has proved useful in this regard. However, hypoxia, which is implicated in tumor growth, has been found to mediate resistance to this type of tumor starvation. Here, we describe the design and testing of a platelet membrane mimetic, PMS, consisting of mesoporous silica nanoparticles (MSNs) loaded with metformin (MET) as an inner layer and platelet membranes (PM) as an outer layer that inhibits oxygen consumption by the tumor cells’ respiratory pathways and enhances the effectiveness of GOx. MET directly inhibits the activity of complex I in mitochondrial electron transport and is thus a potent inhibitor of cell respiration. PMS target tumor tissue effectively and, once internalized, MET can inhibit respiration. When oxygen is plentiful, GOx promotes glucose consumption, allowing amplification of its effects on tumor starvation. This combination of respiratory suppression by PMS and starvation therapy by GOx has been found to be effective in both targeting tumors and inhibiting their growth. It is hoped that this strategy will shed light on the development of next-generation tumor starvation treatments.

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“…Moreover, in vivo biodistribution studies displayed the theragnostic capabilities of these NPs, the tumor retention of which was more than twice as high as the uncoated and non-specific membrane-coated groups. Hepatocellular carcinoma (HCC)—specific CAR-T cell membrane-coated nanoparticles have been developed by Yuan et al [ 93 ] for the treatment of HCC. The nanosystem packed with CAR-T cell membranes showed a superior ability to target HCC cells and improved therapeutic effect compared to naked nanosystem, because the CAR-T cell membranes specifically recognize GPC3+ HCC cells.…”

Section: T-cell Membranesmentioning

confidence: 99%

Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy

Gong

Wang

Zhang

et al. 2020

Cancers

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Despite the advances in surface bioconjugation of synthetic nanoparticles for targeted drug delivery, simple biological functionalization is still insufficient to replicate complex intercellular interactions naturally. Therefore, these foreign nanoparticles are inevitably exposed to the immune system, which results in phagocytosis by the reticuloendothelial system and thus, loss of their biological significance. Immunocyte membranes play a key role in intercellular interactions, and can protect foreign nanomaterials as a natural barrier. Therefore, biomimetic nanotechnology based on cell membranes has developed rapidly in recent years. This paper summarizes the development of immunocyte membrane-coated nanoparticles in the immunotherapy of tumors. We will introduce several immunocyte membrane-coated nanocarriers and review the challenges to their large-scale preparation and application.

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Coating biomimetic nanoparticles with chimeric antigen receptor T cell-membrane provides high specificity for hepatocellular carcinoma photothermal therapy treatment

Cited by 162 publications

References 51 publications

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy

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