Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

Abstract

Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m−1 and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm2kg−1, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.

Improvement of Hyperthermia Properties of Iron Oxide Nanoparticles by Surface Coating

“…Very large increases in the SLP were observed with the in situ coating via polyvinylpyrrolidone (PVP) or fucoidan treatments in the order of 60 and 230%, respectively. This was attributed to the role of coating agents in the surface stabilization of NPs, as well as to the growth modifiers acting on the size of NPs, on which the saturation magnetization depends. , …”

“…This was attributed to the role of coating agents in the surface stabilization of NPs, as well as to the growth modifiers acting on the size of NPs, on which the saturation magnetization depends. 81,83 3.5. Analysis of Nanoparticle Solution Stability.…”

A critical review on extraction, characteristics, physicochemical activities, potential health benefits, and industrial applications of fucoidan

“…The antitumoral activity of these polymers was investigated. The results showed that fucoidan and fucoidan‐coated NP are biocompatible (Gonçalves et al, 2021).…”

Fe3O4-Nanoparticle-Doped Epoxy Resin as a Detachable Adhesive by Electromagnetic Heating for GFRP Single-Lap Joints

“…Through electrothermal activation, the EM heating enables targeted heating, as well as less energy consumption when compared to conventional heating. For this reason, it can be used for a wide range of applications, such as the welding of thermoplastic composites [ 28 ] or acerated curing of adhesives [ 29 , 30 ], among others, such as biomedical purposes [ 31 ].…”