Coating small-diameter ePTFE vascular grafts with tunable poly(diol-<i>co</i>-citrate-<i>co</i>-ascorbate) elastomers to reduce neointimal hyperplasia

Yu, Lu; Newton, Emily R.; Gillis, David C.; Sun, Kui; Cooley, Brian C.; Keith, Andrew N.; Sheiko, Sergei S.; Tsihlis, Nick D.; Kibbe, Melina R.

doi:10.1039/d1bm00101a

Cited by 13 publications

(6 citation statements)

References 59 publications

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“…A generally accepted root cause of these issues is the poor interaction of cells and the non-specific adsorption of proteins onto the graft, which lead to platelet aggregation but fail to form organized endothelium and/or matured smooth muscle. To circumvent these issues, bioengineering strategies including chemical coatings, materials modifications with peptides, proteins or other biomolecules, and seedings of endothelial cells or stem cells on inert or degradable grafts, have been utilized, with the goal of better integrating grafts with the native vasculature ( Hielscher et al, 2018 ; Wang et al, 2020 ; Ham et al, 2021 ; Liu et al, 2021 ; Yu et al, 2021 ). Results with these strategies demonstrated improved endothelialization and/or inhibited thrombosis, inflammation, intimal hyperplasia, or infection.…”

Section: Factors Impairing Healing or Regeneration Around Vascular Gr...mentioning

confidence: 99%

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Tan

Boodagh

Parthiban

et al. 2023

Front. Bioeng. Biotechnol.

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Vascular grafts are widely used for vascular surgeries, to bypass a diseased artery or function as a vascular access for hemodialysis. Bioengineered or tissue-engineered vascular grafts have long been envisioned to take the place of bioinert synthetic grafts and even vein grafts under certain clinical circumstances. However, host responses to a graft device induce adverse remodeling, to varied degrees depending on the graft property and host’s developmental and health conditions. This in turn leads to invention or failure. Herein, we have mapped out the relationship between the design constraints and outcomes for vascular grafts, by analyzing impairment factors involved in the adverse graft remodeling. Strategies to tackle these impairment factors and counteract adverse healing are then summarized by outlining the research landscape of graft innovations in three dimensions—cell technology, scaffold technology and graft translation. Such a comprehensive view of cell and scaffold technological innovations in the translational context may benefit the future advancements in vascular grafts. From this perspective, we conclude the review with recommendations for future design endeavors.

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Section: Factors Impairing Healing or Regeneration Around Vascular Gr...mentioning

confidence: 99%

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Tan

Boodagh

Parthiban

et al. 2023

Front. Bioeng. Biotechnol.

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“…Neointimal hyperplasia is a major cause of failure of small-diameter vascular grafts after implantation ( Reinhardt. et al, 2019 ; Lopera Higuita and Griffiths, 2020a ; Yu et al, 2021 ). The development of the neointima involves interactions between serum proteins, platelets, inflammatory proteins/cells, fibroblasts/smooth muscle cell -like cells and endothelial cells (Reinhardt.…”

Section: Introductionmentioning

confidence: 98%

Vascular endothelial growth factor attenuates neointimal hyperplasia of decellularized small-diameter vascular grafts by modulating the local inflammatory response

Xie

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Small-diameter vascular grafts (diameter <6 mm) are in high demand in clinical practice. Neointimal hyperplasia, a common complication after implantation of small-diameter vascular grafts, is one of the common causes of graft failure. Modulation of local inflammatory responses is a promising strategy to attenuates neointimal hyperplasia. Vascular endothelial growth factor (VEGF) is an angiogenesis stimulator that also induces macrophage polarization and modulates inflammatory responses. In the present study, we evaluated the effect of VEGF on the neointima hyperplasia and local inflammatory responses of decellularized vascular grafts. In the presence of rhVEGF-165 in RAW264.6 macrophage culture, rhVEGF-165 induces RAW264.6 macrophage polarization to M2 phenotype. Decellularized bovine internal mammary arteries were implanted into the subcutaneous and infrarenal abdominal aorta of New Zealand rabbits, with rhVEGF-165 applied locally to the adventitial of the grafts. The vascular grafts were removed en-bloc and submitted to histological and immunofluorescence analyses on days 7 and 28 following implantation. The thickness of the fibrous capsule and neointima was thinner in the VEGF group than that in the control group. In the immunofluorescence analysis, the number of M2 macrophages and the ratio of M2/M1 macrophages in vascular grafts in the VEGF group were higher than those in the control group, and the proinflammatory factor IL-1 was expressed less than in the control group, but the anti-inflammatory factor IL-10 was expressed more. In conclusion, local VEGF administration attenuates neointimal hyperplasia in decellularized small-diameter vascular grafts by inducing macrophage M2 polarization and modulating the inflammatory response.

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“…On the contrary, synthetic polymers have a consistent composition and are easier to process into scaffolds. An important group of materials is polyesters; among which, poly(diols citrates) have recently gained importance [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…The majority of research to date has focused on poly(1,8-octanediol citrate) (POC). POC-based materials show hemocompatibility and reduce the risk of thrombus formation compared to the commonly used polymers [ 24 , 29 , 31 , 32 , 33 ]. This work covers the synthesis of poly(1,4-butanediol citrate), its mathematical description and the preparation and testing of polymer films.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Cytotoxicity Studies of Poly(1,4-butanediol citrate) Gels for Cell Culturing

Bandzerewicz,

Niebuda,

Gadomska-Gajadhur

2023

Gels

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One of the main branches of regenerative medicine is biomaterials research, which is designed to develop and study materials for regenerative therapies, controlled drug delivery systems, wound dressings, etc. Research is continually being conducted to find biomaterials—especially polymers—with better biocompatibility, broader modification possibilities and better application properties. This study describes a potential biomaterial, poly(1,4-butanediol citrate). The gelation time of poly(1,4-butanediol citrate) was estimated. Based on this, the limiting reaction time and temperature were determined to avoid gelling of the reaction mixture. Experiments with different process conditions were carried out, and the products were characterised through NMR spectra analysis. Using statistical methods, the functions were defined, describing the dependence of the degree of esterification of the acid groups on the following process parameters: temperature and COOH/OH group ratio. Polymer films from the synthesised polyester were prepared and characterised. The main focus was assessing the initial biocompatibility of the materials.

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Coating small-diameter ePTFE vascular grafts with tunable poly(diol-co-citrate-co-ascorbate) elastomers to reduce neointimal hyperplasia

Abstract: Lack of long-term patency has hindered the clinical use of small-diameter prosthetic vascular grafts with the majority of these failures due to the development of neointimal hyperplasia. Previous studies by...

Cited by 13 publications

References 59 publications

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Vascular endothelial growth factor attenuates neointimal hyperplasia of decellularized small-diameter vascular grafts by modulating the local inflammatory response

Synthesis and Cytotoxicity Studies of Poly(1,4-butanediol citrate) Gels for Cell Culturing

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