Coatings based on calcium phosphates for metallic medical implants

Иевлев, В. М.

doi:10.1070/rc2013v082n02abeh004331

Cited by 11 publications

(3 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, a significant difference was found between Nd:YAG and KrF lasers and CaPO 4 deposits: KrF deposits have a columnar structure, while Nd:YAG ones are granular [287,288]. This example clearly shows that the mechanism of laser ablation of CaPO 4 is very complex and it is described in reference [320].…”

Section: Pulsed Laser Deposition (Pld)mentioning

confidence: 80%

“…These features determine the structure and properties of the deposit: the presence of amorphous phases (ACP), high hardness and bond strength, and the reproduction of the initial elemental composition of the target in the deposit. Mass transfer with preservation of composition is due to the high heating rate and thermal ablation of the target in the laser spot region [320].…”

Section: Pulsed Laser Deposition (Pld)mentioning

confidence: 99%

“…In the preparation of sols, inorganic salts and/or organic elemental compounds such as alkoxides are usually used as precursors. For example, when synthesizing HA, orthophosphate precursors consist of H 3 PO 4 , P 2 O 5 , P(OC 2 H 5 ) 3 and (NH 4 ) 3 PO 4 dissolved in ethanol, while calcium precursors are Ca(CH 3 COO) 2 •H 2 O and Ca(NO 3 ) 2 •4H 2 O [320,461]. In addition, Ca glycosides and Ca(OC 2 H 5 ) 2 precursors can also be used, but the latter must be dissolved in a non-aqueous solvent.…”

Section: Sol-gel Depositionmentioning

confidence: 99%

See 2 more Smart Citations

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Dorozhkin

2023

J. Compos. Sci.

View full text Add to dashboard Cite

A The present overview describes various production techniques for biocompatible calcium orthophosphate (abbreviated as CaPO4) deposits (coatings, films and layers) on the surfaces of various types of substrates to impart the biocompatible properties for artificial bone grafts. Since, after being implanted, the grafts always interact with the surrounding biological tissues at the interfaces, their surface properties are considered critical to clinical success. Due to the limited number of materials that can be tolerated in vivo, a new specialty of surface engineering has been developed to desirably modify any unacceptable material surface characteristics while maintaining the useful bulk performance. In 1975, the development of this approach led to the emergence of a special class of artificial bone grafts, in which various mechanically stable (and thus suitable for load-bearing applications) implantable biomaterials and artificial devices were coated with CaPO4. Since then, more than 7500 papers have been published on this subject and more than 500 new publications are added annually. In this review, a comprehensive analysis of the available literature has been performed with the main goal of finding as many deposition techniques as possible and more than 60 methods (double that if all known modifications are counted) for producing CaPO4 deposits on various substrates have been systematically described. Thus, besides the introduction, general knowledge and terminology, this review consists of two unequal parts. The first (bigger) part is a comprehensive summary of the known CaPO4 deposition techniques both currently used and discontinued/underdeveloped ones with brief descriptions of their major physical and chemical principles coupled with the key process parameters (when possible) to inform readers of their existence and remind them of the unused ones. The second (smaller) part includes fleeting essays on the most important properties and current biomedical applications of the CaPO4 deposits with an indication of possible future developments.

show abstract

Section: Pulsed Laser Deposition (Pld)mentioning

confidence: 80%

Section: Pulsed Laser Deposition (Pld)mentioning

confidence: 99%

Section: Sol-gel Depositionmentioning

confidence: 99%

See 1 more Smart Citation

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Dorozhkin

2023

J. Compos. Sci.

View full text Add to dashboard Cite

show abstract

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Agarwal

Garcı́a

2015

Advanced Drug Delivery Reviews

635

399

View full text Add to dashboard Cite

Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone defects and complex fractures still present a significant challenge to the medical community. Current treatments center on metal implants for structural and mechanical support and auto- or allo-grafts to substitute long bone defects. Metal implants are associated with several complications such as implant loosening and infections. Bone grafts suffer from donor site morbidity, reduced bioactivity, and risk of pathogen transmission. Surgical implants can be modified to provide vital biological cues, growth factors and cells in order to improve osseointegration and repair of bone defects. Here we review strategies and technologies to engineer metal surfaces to promote osseointegration with the host tissue. We also discuss strategies for modifying implants for cell adhesion and bone growth via integrin signaling and growth factor and cytokine delivery for bone defect repair.

show abstract

Simple coating with fibronectin fragment enhances stainless steel screw osseointegration in healthy and osteoporotic rats

et al. 2015

View full text Add to dashboard Cite

Metal implants are widely used to provide structural support and stability in current surgical treatments for bone fractures, spinal fusions, and joint arthroplasties as well as craniofacial and dental applications. Early implant-bone mechanical fixation is an important requirement for the successful performance of such implants. However, adequate osseointegration has been difficult to achieve especially in challenging disease states like osteoporosis due to reduced bone mass and strength. Here, we present a simple coating strategy based on passive adsorption of FN7-10, a recombinant fragment of human fibronectin encompassing the major cell adhesive, integrin-binding site, onto 316-grade stainless steel (SS). FN7-10 coating on SS surfaces promoted α5β1 integrin-dependent adhesion and osteogenic differentiation of human mesenchymal stem cells. FN7-10-coated SS screws increased bone-implant mechanical fixation compared to uncoated screws by 30% and 45% at 1 and 3 months, respectively, in healthy rats. Importantly, FN7-10 coating significantly enhanced bone-screw fixation by 57% and 32% at 1 and 3 months, respectively, and bone-implant ingrowth by 30% at 3 months compared to uncoated screws in osteoporotic rats. These coatings are easy to apply intra-operatively, even to implants with complex geometries and structures, facilitating the potential for rapid translation to clinical settings.

show abstract

Coatings based on calcium phosphates for metallic medical implants

Cited by 11 publications

References 90 publications

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Simple coating with fibronectin fragment enhances stainless steel screw osseointegration in healthy and osteoporotic rats

Contact Info

Product

Resources

About