Coatings of tablets dissolving in the gastrointestinal tract (literature review)

Proof‐of‐concept study on the suitability of 13C‐urea as a marker substance for assessment of in vivo behaviour of oral colon‐targeted dosage forms

“…, 1991). In earlier days, the transit of a dosage form through the GIT was visualized by using X‐ray radiography with barium sulphate as a contrast substance (Lark‐Horovitz, 1941; Efimova and Minina, 1969). Today, γ‐scintigraphy as a molecular imaging technology is considered to be the state‐of‐the art imaging technology (Digenis et al.…”

“…Characterization of the in vivo release profile of oral drug delivery systems is generally performed by conventional pharmacokinetic assessment in combination with an imaging technology (Coupe et al, 1991). In earlier days, the transit of a dosage form through the GIT was visualized by using X-ray radiography with barium sulphate as a contrast substance (Lark-Horovitz, 1941;Efimova and Minina, 1969). Today, g-scintigraphy as a molecular imaging technology is considered to be the stateof-the art imaging technology (Digenis et al, 2000;Wilding et al, 2001;Damle et al, 2002;Willmann et al, 2008).…”