Coatings of titanium substrates with xCaO·(1 − x)SiO 2 sol–gel materials: characterization, bioactivity and biocompatibility evaluation

Catauro, Michelina; Papale, Ferdinando; Bollino, Flavia

doi:10.1016/j.msec.2015.09.033

Cited by 39 publications

(33 citation statements)

References 40 publications

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“…Among the 52 papers, 11 have studied pure BGs, 23 have assessed doped‐glasses, and 18 have used composite materials …”

Section: Resultsmentioning

confidence: 99%

“…Glasses produced by sol–gel can be also used to make thin films in order to cover substrates such as titanium or to form substrate for HA growth . The surface particles can be chemically modified to change the surface charge in order to control directly glass particle‐to‐cell interaction/internalization/repulsion.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, BGs were used to trigger cells differentiation in other ways. For instance, they were used as a carrier to delivery siRNA or as a thin film to cover sheets of Ti6A14V titanium alloy for improved cell adhesion …”

Section: Pure Bgsmentioning

confidence: 99%

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Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

et al. 2018

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Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol-gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses (PRISMA) statement. The research ranged 5 years' window time (from January, 01, 2012, to August, 31, 2017) and the relevant studies were identified based on the inclusion/exclusion criteria. A total of 45 articles were selected from 244 initial returns, plus seven further articles coming from other sources were selected for the same purpose. From this systematic study, it is revealed that only 13 of the 52 articles have proved both the ability of BGs to differentiate dental cells at genetic level and their ability of triggering cell-mediated mineralization, but only six of them showed, along with cells, the antibacterial properties of the glasses. This review shows that sol-gel BGs are not toxic, can sustain cell proliferation and differentiation at a genetic level, and can keep the bacterial population under control. Moreover, a standard methodology and an ideal material are suggested. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part B, 2018.

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“…Among the 52 papers, 11 have studied pure BGs, 23 have assessed doped‐glasses, and 18 have used composite materials …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

et al. 2018

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“…A large group of coating materials are metal oxides. The growing number of their applications include: electronics, microelectronics and photonics , optics , energy acquisition and processing , surface‐chemistry engineering , biomedical applications , and many more. The wide application range of oxide coatings as well as variety of substrates materials results in a diversity of production methods.…”

Section: Introductionmentioning

confidence: 99%

Zirconia coatings deposited by novel plasma‐enhanced aerosol–gel method

Miszczak

Pietrzyk

Kucharski

2015

Physica Status Solidi (a)

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The sol-gel technique is well known and widely used for manufacturing coatings. An aerosol-gel method is a modification of the classic sol-gel process. Preparation of coatings by this technique involves the formation of an aerosol and its deposition on the coated surfaces, where the aerosol droplets merge into a continuous layer. In this work, an aerosol-gel routine, enhanced with a low-temperature plasma discharge, was used to produce zirconia coatings on different substrates. Low-temperature plasma was used for preactivation of substrate surfaces prior to the sol deposition, and for treatment of deposited layers. The obtained coatings were characterized using optical, electron (SEM), and atomic force (AFM) microscopes, a contact-angle device, a scratch tester, a grazingincidence X-ray diffractometer (GIXRD), and an infrared spectrometer (FTIR). The results showed a significant influence of substrate plasma pretreatment on the formation and morphology of zirconia thin films. A noticeable effect of low-temperature plasma treatment on the structure and properties of the obtained coatings was also presented. These results allow possible applications of this method for the preparation of zirconia coatings on temperature-sensitive substrates to be predicted.

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“…Indeed, soluble silica and calcium ions are able to activate and stimulate osteoprogenitor cells at the implant site, promoting bone tissue growth. These materials have also demonstrated the ability to form hydroxyapatite on their surface in vitro [13,14]. However, the brittleness of sol-gel materials limits their use in several load-bearing applications.…”

mentioning

confidence: 99%

Advanced Glass-Ceramic Materials for Biomedical Applications

Catauro¹,

Bollino²

2017

Bone Rep Recommendations

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Biomaterial science studies the interactions that occur between materials and tissues in order to understand the mechanisms that lead to material integration in biological systems for medical purposes. It is a field that requires a multidisciplinary approach, integrating materials science, chemistry, biology, engineering and medicine. Its development arose out of the requirement for new materials with high performance in terms of tolerability and integration capability that can be used to replace or restore function to a body tissue. Despite advances in the biomaterials field, at this point in time a satisfactory combination between the properties of the materials (mechanical, chemical and tribological) and their biocompatibility has not yet been achieved. This is the cause of early failure of implants, which necessitates subsequent replacement of prosthetic devices, especially in young patients. Glass-ceramics are an important family of materials proposed for bone repair and substitution. They have the capability to bond with living bone by forming a hydroxyapatite layer with a composition similar to that of the mineral phase of bone [1]. The first bioglass (45S5) was discovered in 1971 by Hench at al. [2]. Afterwards many other glasses with various compositions were explored [3]. Kokubo et al. [4] developed Apatite-Wollastonite (A-W) glass-ceramics which retains a high mechanical strength in vivo for a long period and is able to bond to living bone in a short space of time. Moreover, published literature [5] shows that the preparation method, in addition to the material composition, also affects the resulting structure and, thus, the biological properties of the materials obtained. An ideal technique to prepare bioglass is the sole-gel method, a versatile synthesis technique used to produce glasses and ceramics at low temperatures. The process starts when water is added to a solution of metal alkoxide precursors in alcohol. The hydrolysis of the metal alkoxide and the polycondensation of the oligomers formed cause a transition of the system from a mostly colloidal liquid ('sol') into a solid 'gel'. By drying the obtained wet gel, it is possible to prepare xerogels (by exposure to low temperatures) or aerogels (by solvent extraction under supercritical conditions) or dense ceramic and glass by means of a further heat treatment at higher temperatures. Glasses and ceramics synthesized via the sol-gel method exhibit higher bioactivity and biocompatibility than materials with the same composition but prepared using other techniques [6]. Indeed, sol-gel-derived glasses have an inherent mesoporosity that gives them a larger surface area and degradation rates potentially more rapid than melt-derived glasses of similar composition. Moreover, the presence of -OH groups on their surface stimulates hydroxyapatite nucleation, promoting their easier Osseo integration. Sol-gel glasses and ceramics have been proposed for many biomedical applications, such as artificial dental roots, bone regenerative materials, coatings to...

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Coatings of titanium substrates with xCaO·(1 − x)SiO 2 sol–gel materials: characterization, bioactivity and biocompatibility evaluation

Cited by 39 publications

References 40 publications

Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

Zirconia coatings deposited by novel plasma‐enhanced aerosol–gel method

Advanced Glass-Ceramic Materials for Biomedical Applications

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