Coats Disease: Smaller Volume of the Affected Globe

Abstract

A significantly smaller volume of the affected globe is an additional feature of Coats disease.

Is CT Still Useful in the Study Protocol of Retinoblastoma?

“…Imaging studies are used for diagnostic purposes only in very selected instances, as in cases in which ophthalmoscopy is impossible, such as with the presence of opaque ocular refractive media and massive retinal detachment or for differentiating lesions simulating retinoblastoma. 11,[14][15][16][17][18][19][20][21][22][23] The purpose of this study was to assess the utility of the association of ophthalmologic evaluation and MR imaging in the detection of intralesional calcifications in retinoblastoma, to evaluate whether CT is still mandatory in the protocol study of retinoblastoma and simulating lesions.…”

Leukocoria: Clinical and Neuroradiological Findings

“…The disease usually appears in patients slightly older (4-8 years) than those affected by RB. Several exceptions to the usual age at presentation have been reported 20,47,49 . Coat's disease is isolated in the majority of cases although associations with faciocapsulohumeral muscular dystrophy, Turner's syndrome, Senior-Loken syndrome, the ichthyosis hystrix variant of epidermal nevus syndrome, inversion on chromosome 3, and a deletion on chromosome 13 50 have been described.…”

“…Computed tomography (CT) and/or magnetic resonance (MR) imaging are required to detect spread beyond the eye, or intracranial disease, and are used for diagnostic purposes only in selected instances, such as the presence of opaque ocular refractive media or retinal detachment, or to differentiate lesions simulating retinoblastoma [12][13][14][15][16][17][18][19][20][21][22] . The detection of intraocular calcium Figure 10 Axial T1-weighted spin-echo MR image after contrast medium administration.…”

Imaging of Pediatric Orbital Diseases

“…22,24 Coats disease is unilateral in 80% to 90% of cases, with a male predilection. Common signs are leukocoria and strabismus.…”

“…Common signs are leukocoria and strabismus. 22,24 On CT, Coats disease appears as a hyperdense exudate, typically without calcification (Fig. 13).…”