Coats' syndrome: long term follow up

Abstract

Aim-To increase the understanding of the long term results in pseudoretinoblastoma eyes with infantile Coats' syndrome. Methods-This study design was a retrospective case review. 10 patients were analysed who were initially referred with a diagnosis of retinoblastoma but had Coats' syndrome on the basis of ocular oncological evaluation. Vision, fundus photography, ultrasonography, and computed tomography scans were obtained and evaluated. Changes in vision and retinal status were measured. Results-The initial age at presentation was 2.4 years (range 0.25-4 years). All patients had retinal detachment at diagnosis. Nine of 10 retinas were reattached after various treatments. Reattached retinas had closure of peripheral telangiectasia and visible intraretinal crystals. Vision was dismal. At last follow up (mean 8.8 years), only two patients had 20/400 or better visual acuities. Five eyes had no light perception despite early treatment to reattach the retina. Nine of 10 eyes remain cosmetically acceptable. One patient wore a cosmetic shell. Conclusions-Long term results indicate that these eyes can be salvaged and the retina reattached but the visual outcome is poor. (Br J Ophthalmol 2000;84:37-39)

A population-based study of Coats disease in the United Kingdom I: epidemiology and clinical features at diagnosis

“…1,7,[9][10][11] While previous studies have been Coats disease in the United Kingdom 1: epidemiology and presenting features B Morris et al enlightening they did not seem to reflect the cases of Coats disease we have typically encountered in clinical practise. On the other hand, the smaller numbers in our study could make the differences observed to be a chance rather than a real occurrence.…”

“…This difference may be because many younger children were referred to the ocular oncology at Wills Eye Hospital because of concern about possible underlying retinoblastoma by the referring doctor (27% of cases). 1 Indeed, in a different series of 10 children with Coats disease reported by Char 11 , and who were originally referred because of suspected retinoblastoma, the mean age at diagnosis was just 2.4 years (29 months).…”

A population-based study of Coats disease in the United Kingdom II: investigation, treatment, and outcomes

“…[6][7][8] It is not surprising therefore that an examination under anaesthesia was performed in a significant proportion of cases (42%), and that ultrasound (26%) and FFA (35%) were also used extensively. Somewhat surprisingly in our series, in 18 cases (32.7%) no investigations were carried out in addition to the clinical examination.…”

Enfermedad de Coats tratada con bevacizumab (Avastin®)

“…El tratamiento óptimo en los casos de enfermedad de Coats que cursan con desprendimiento de retina sigue siendo incierto. Algunos autores han sugerido que la crioterapia resulta más efectiva en los casos más graves (4). La fotocoagulación con láser es efectiva solamente si la retina no se encuentra desprendida.…”