Coaxial Electrohydrodynamic Atomization for the Production of Drug-Loaded Micro/Nanoparticles

Chen, Chuanpin; Liu, Wenfang; Jiang, Ping; Hong, Tingting

doi:10.3390/mi10020125

Cited by 25 publications

(14 citation statements)

References 102 publications

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“…Therefore, the volume dose of microbubble may be a new direction to investigate the therapeutic effect of drug-loaded microbubbles. By increasing the concentration of microbubbles prepared, it is expected to improve the therapeutic efficiency of drug-loaded microbubble [124, 125]. As the important characterization parameter of drug-loaded microbubbles, entrapment efficiency refers to the ratio of the amount of drugs wrapped into microbubbles to the total dosage and drug-loading capacity refers to the ratio of the amount of medicine wrapped into microbubbles to the total weight of the microbubble [126].…”

Section: Discussionmentioning

confidence: 99%

Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy

Gong

Gao

Liu

et al. 2019

BioMed Research International

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Cardiac-cerebral thrombosis and malignant tumor endanger the safety of human life seriously. Traditional chemotherapy drugs have side effects which restrict their applications. Drug-loaded microbubbles can be destroyed by ultrasound irradiation at the focus position and be used for thrombolysis and tumor therapy. Compared with traditional drug treatment, the drug-loaded microbubbles can be excited by ultrasound and release drugs to lesion sites, increasing the local drug concentration and the exposure dose to nonfocal regions, thus reducing the cytotoxicity and side effects of drugs. This article reviews the applications of drug-loaded microbubbles combined with ultrasound for thrombolysis and tumor therapy. We focus on highlighting the advantages of using this new technique for disease treatment and concluding with recommendations for future efforts on the applications of this technology.

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Section: Discussionmentioning

confidence: 99%

Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy

Gong

Gao

Liu

et al. 2019

BioMed Research International

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“…Polymer ES is currently being increasingly used for encapsulation, especially in biomedical applications such as drug delivery. The polymer used determines the release kinetics of the core and at the same time protects the encapsulated additive against degradation and the loss of biological activity [169,170].…”

Section: Encapsulation Methodsmentioning

confidence: 99%

Electrospray: More than just an ionization source

et al. 2020

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is a potential-driven process of liquid atomization, which is employed in the field of analytical chemistry, particularly as an ionization technique for mass spectrometric analyses of biomolecules. In this review, we demonstrate the extraordinary versatility of the electrospray by overviewing the specifics and advanced applications of ESbased processing of low molecular mass compounds, biomolecules, polymers, nanoparticles, and cells. Thus, under suitable experimental conditions, ES can be used as a powerful tool for highly controlled deposition of homogeneous films or various patterns, which may sometimes even be organized into 3D structures. We also emphasize its capacity to produce composite materials including encapsulation systems and polymeric fibers. Further, we present several other, less common ES-based applications. This review provides an insight into the remarkable potential of ES, which can be very useful in the designing of innovative and unique strategies.

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“…This technique permits the simultaneous encapsulation of hydrophobic and hydrophilic drugs, with no loss of biological activity, for effective delivery at the targeted site [186,187]. It is also possible to control the material flow rate and synthesis of uniform double-walled microspheres [188].…”

Section: Coaxial Electro-sprayingmentioning

confidence: 99%

Stimulus-responsive sequential release systems for drug and gene delivery

et al. 2020

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In recent years, a range of studies have been conducted with the aim to design and characterize delivery systems that are able to release multiple therapeutic agents in controlled and programmed temporal sequences, or with spatial resolution inside the body. This sequential release occurs in response to different stimuli, including changes in pH, redox potential, enzyme activity, temperature gradients, light irradiation, and by applying external magnetic and electrical fields. Sequential release (SR)-based delivery systems, are often based on a range of different micro-or nanocarriers and may offer a silver bullet in the battle against various diseases, such as cancer. Their distinctive characteristic is the ability to release one or more drugs (or release drugs along with genes) in a controlled sequence at different times or at different sites. This approach can lengthen gene expression periods, reduce the side effects of drugs, enhance the efficacy of drugs, and induce an anti-proliferative effect on cancer cells due to the synergistic effects of genes and drugs. The key objective of this review is to summarize recent progress in SR-based drug/gene delivery systems for cancer and other diseases.

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Coaxial Electrohydrodynamic Atomization for the Production of Drug-Loaded Micro/Nanoparticles

Cited by 25 publications

References 102 publications

Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy

Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy

Electrospray: More than just an ionization source

Stimulus-responsive sequential release systems for drug and gene delivery

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