Coaxial Electrospinning with Mixed Solvents: From Flat to Round Eudragit L100 Nanofibers for Better Colon‐Targeted Sustained Drug Release Profiles

Yu, Deng‐Guang; Xu, Ying; Li, Zan; Du, Lin-Ping; Zhao, Ben-Guo; Wang, Xia

doi:10.1155/2014/967295

Cited by 32 publications

(26 citation statements)

References 21 publications

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“…These examples exploit a spinnable sheath fluid to process an unspinnable core, but it is also possible to work with an unspinnable shell and a spinnable core. Such modified coaxial processes often use shell fluids to prevent clogging during the electrospinning processes [160][161][162].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

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The development of oral dosage forms for poorly water-soluble active pharmaceutical ingredients (APIs) is a persistent challenge. A range of methods has been explored to address this issue, and amorphous solid dispersions (ASDs) have received increasing attention. ASDs are typically prepared by starting with a liquid precursor (a solution or melt) and applying energy for solidification. Many techniques can be used, with the emergence of electrospinning as a potent option in recent years. This method uses electrical energy to induce changes from liquid to solid. Through the direct applications of electrical energy, electrospinning can generate nanofiber-based ASDs from drug-loaded solutions, melts and melt-solutions. The technique can also be combined with other approaches using the application of mechanical, thermal or other energy sources. Electrospinning has numerous advantages over other approaches to produce ASDs. These advantages include extremely rapid drying speeds, ease of implentation, compatibility with a wide range of active ingredients (including those which are thermally labile), and the generation of products with large surface areas and high porosity. Furthermore, this technique exhibits the potential to create so-called 'fifth-generation' ASDs with nanostructured architectures, such as core/shell or Janus systems and their combinations. These advanced systems can improve dissolution behaviour and provide programmable drug release profiles. Additionally, the fiber components and their spatial distributions can be precisely controlled. Electrospun fiber-based ASDs can maintain an incorporated active ingredient in the amorphous physical form for prolonged periods of time because of their homogeneous drug distribution within the polymer matrix (typically they comprise solid solutions), and ability to inhibit molecular motion. These ASDs can be utilised to generate oral dosage forms for poorly water-soluble drugs, resulting in linear or multiple-phase release of one or more APIs. Electrospun ASDs can also be exploited as templates for manipulating molecular self-assembly, offering a bridge between ASDs and other types of dosage forms. This review addresses the development, advantages and pharmaceutical applications of electrospinning for producing polymeric ASDs. Material preparation and analysis procedures are considered. The mechanisms through which performance has been improved are also discussed.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

Self Cite

250

156

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“…The technique essentially involves making a solution of a polymer (often with a functional component) in a volatile solvent, and ejecting this from a syringe fitted with a metal needle (the spinneret). A high potential difference is applied between the spinneret and a grounded collector, and the electrical energy causes rapid evaporation of the solvent and yields one-dimensional polymer-based fibers [12][13][14] .…”

Section: Shown Inmentioning

confidence: 99%

From Traditional Spinning to Advanced Electrospinning—Material Engineering Teaching in High School

Liu¹,

Xiu²,

Zhang³

et al. 2017

dtssehs

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Abstract. In the teaching of material engineering in high school, a comparison between a traditional technique and an advanced one not only can effectively promote the students to understand and grasp the new one, but also can be used as a useful tool to encourage the student to do more self-learning about material processing. In the present report, the students were taught to carry out the advanced electrospinning processes. The difficulties in clear explanations the complicated new process in the class could be easily overcome by the usage of traditional wet spinning as a start point. Based on their past knowledge and experience about the wet spinning processes, the college students majoring in material engineering quickly grasped the essences of electrospinning, discriminated the differences between electrospinning and wet spinning. Some students eagerly went to the experimental laboratory to carry out some experiments about the preparations and characterizations of electrospun polymeric nanofibers. A related start point for comparison is important to transfer knowledge about a new advanced material processing technique to the college students.

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“…1, (1) a pump for driving and measuring the flow rate of working fluids; (2) a spinneret for directing the working fluids to the coagulation bath; (3) a coagulation bath for the solidification of working fluid; ans (4) a winding apparatus for drawing and collecting the polymeric fiber products [7]. Electrospinning, sharing characteristics of both electrospraying and conventional solution dry spinning, is a non-invasive process, requiring no usage of coagulation chemistry or high temperatures for generating solid threads from solution [8][9][10]. As shown in Fig.…”

Section: Concepts About Traditional Wet Spinning Process and The Singmentioning

confidence: 99%

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

Xiu¹,

Liu²,

Tan³

et al. 2017

dtssehs

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Abstract. In higher education, the cultivation of innovation ability is very important for the college students. However, how to train innovative thinking is often a big concern for their teachers. In this paper, a simple way is shown, which is about how to guide the students to learn and to think about the evolution of a series of material processing technologies. With the integration of concepts from traditional wet spinning process with those from the single-fluid electrospinning, the modified coaxial electrospinning was hatched out from the traditional coaxial one. This evolution process comprises an excellent example to explain to the college students majoring in Materials Science and Engineering about engineering innovation. The thinking and explaining paradigm manifested in this example not only will be useful for the students to grasp new advanced technologies, promote them to do practical innovations, but also should be very useful for a wide variety of engineering disciplines to effectively take innovative engineering educations.

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Coaxial Electrospinning with Mixed Solvents: From Flat to Round Eudragit L100 Nanofibers for Better Colon‐Targeted Sustained Drug Release Profiles

Cited by 32 publications

References 21 publications

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

From Traditional Spinning to Advanced Electrospinning—Material Engineering Teaching in High School

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

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