Coaxial Electrospinning with Triton X‐100 Solutions as Sheath Fluids for Preparing PAN Nanofibers

Yu, Deng‐Guang; Chatterton, Nicholas P.; Yang, Jing; Wang, Xia; Liao, Yaozu

doi:10.1002/mame.201100258

Cited by 43 publications

(20 citation statements)

References 43 publications

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“…With the jet gradually thinning, its continuously increasing surface area will accelerate solvent evaporation and fluid jet solidification to generate nanofibers. Thus, the additives in polymer solutions used for spinning, such as drug molecules, salts, and surfactants, exert a certain influence on the process [128][129][130][131][132][133], and on the properties of the resultant fibers. This has not been widely explored, and only a few publications describe the influence of APIs on the electrospinning of polymer solutions [111,112].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

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The development of oral dosage forms for poorly water-soluble active pharmaceutical ingredients (APIs) is a persistent challenge. A range of methods has been explored to address this issue, and amorphous solid dispersions (ASDs) have received increasing attention. ASDs are typically prepared by starting with a liquid precursor (a solution or melt) and applying energy for solidification. Many techniques can be used, with the emergence of electrospinning as a potent option in recent years. This method uses electrical energy to induce changes from liquid to solid. Through the direct applications of electrical energy, electrospinning can generate nanofiber-based ASDs from drug-loaded solutions, melts and melt-solutions. The technique can also be combined with other approaches using the application of mechanical, thermal or other energy sources. Electrospinning has numerous advantages over other approaches to produce ASDs. These advantages include extremely rapid drying speeds, ease of implentation, compatibility with a wide range of active ingredients (including those which are thermally labile), and the generation of products with large surface areas and high porosity. Furthermore, this technique exhibits the potential to create so-called 'fifth-generation' ASDs with nanostructured architectures, such as core/shell or Janus systems and their combinations. These advanced systems can improve dissolution behaviour and provide programmable drug release profiles. Additionally, the fiber components and their spatial distributions can be precisely controlled. Electrospun fiber-based ASDs can maintain an incorporated active ingredient in the amorphous physical form for prolonged periods of time because of their homogeneous drug distribution within the polymer matrix (typically they comprise solid solutions), and ability to inhibit molecular motion. These ASDs can be utilised to generate oral dosage forms for poorly water-soluble drugs, resulting in linear or multiple-phase release of one or more APIs. Electrospun ASDs can also be exploited as templates for manipulating molecular self-assembly, offering a bridge between ASDs and other types of dosage forms. This review addresses the development, advantages and pharmaceutical applications of electrospinning for producing polymeric ASDs. Material preparation and analysis procedures are considered. The mechanisms through which performance has been improved are also discussed.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Williams

et al. 2018

Journal of Controlled Release

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156

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“…The primary reason that the sheath solution acts to thin the nanofibers is that it prevents evaporation of solvents from the surface of the core spinning polymer solutions prematurely, and in turn retains the core jet in a fluid state thus allowing it to be subjected to electrical drawing for a longer period in the unstable region. [26][27][28] During the modified process, the electrospinnable core fluid jets had sufficient viscoelastic forces to balance Coulomb forces so allowing an even and continuous drawing. However, the sheath Ag + solution should break up into separate segments along the core PAN fluid jets due to lack of viscoelasticity at a certain place in the bending and whipping region as determined by the sheath rate ratio.…”

Section: Morphologymentioning

confidence: 99%

“…Later advances involved adding surfactants and salts to the sheath fluids so as to manipulate the conductivity and surface tension of sheath solutions for a better coaxial electrospinning process and produce nanofibers with even smaller diameters and a smooth surface morphology. [23][24][25][26][27][28][29] However in all the abovementioned reports, the modified coaxial electrospinning processes generated nanofibers with improved quality in terms of nanofiber diameter, diameter distribution, as well as nanofiber morphology, but no attempts were made to modify the nanofibers so as to improve their functionality and enhance their nascent efficiency.…”

Section: Introductionmentioning

confidence: 99%

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Yu¹,

Zhou²,

Chatterton³

et al. 2012

IJN

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Background:The objective of this investigation was to develop a new class of antibacterial material in the form of nanofibers coated with silver nanoparticles (AgNPs) using a modified coaxial electrospinning approach. Through manipulation of the distribution on the surface of nanofibers, the antibacterial effect of Ag can be improved substantially. Methods: Using polyacrylonitrile (PAN) as the filament-forming polymer matrix, an electrospinnable PAN solution was prepared as the core fluid. A silver nitrate (AgNO 3 ) solution was exploited as sheath fluid to carry out the modified coaxial electrospinning process under varied sheath-to-core flow rate ratios. Results: Scanning electron microscopy and transmission electron microscopy demonstrated that the sheath AgNO 3 solution can take a role in reducing the nanofibers' diameters significantly, a sheath-to-core flow rate ratio of 0.1 and 0.2 resulting in PAN nanofibers with diameters of 380 ± 110 nm and 230 ± 70 nm respectively. AgNPs are well distributed on the surface of PAN nanofibers. The antibacterial experiments demonstrated that these nanofibers show strong antimicrobial activities against Bacillus subtilis Wb800, and Escherichia coli dh5α. Conclusion: Coaxial electrospinning with AgNO 3 solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. We report an example of the systematic design, preparation, and application of a novel type of antibacterial material coated with AgNPs via a modified coaxial electrospinning methodology.

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“…Third, the solvents for preparing the spinning solutions should not only dissolve a certain amount of drug and polymer in the working solution for efficacious drug content and enough polymer chain-entanglement density necessary to prevent capillary breakup and Rayleigh instability for generating nanofibers with uniform structure but should also make the working solution amicable to the electrospinning process. However, a common failure example of preparing drug-loaded fibers using traditional single fluid electrospinning is the frequent clogging of the spinneret, often thought to be a result of high concentration of polymer in the solutions and/or high volatility of employed solvents (14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Huang

Zou

et al. 2013

AAPS PharmSciTech

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Abstract. This study investigated the preparation of drug-loaded fibers using a modified coaxial electrospinning process, in which only unspinnable solvent was used as sheath fluid. With zein/ibuprofen (IBU) co-dissolving solution and N, N-dimethylformamide as core and sheath fluids, respectively, the drug-loaded zein fibers could be generated continuously and smoothly without any clogging of the spinneret. Field emission scanning electron microscopy and transmission electron microscopy observations demonstrated that the fibers had ribbon morphology with a smooth surface. Their average diameters were 0.94±0.34 and 0.67±0.21 μm when the sheath-to-core flow rate ratios were taken as 0.11 and 0.25, respectively. X-ray diffraction and differential scanning calorimetry verified that IBU was in an amorphous state in all fiber composites. Fourier transform infrared spectra showed that zein had good compatibility with IBU owing to hydrogen bonding. In vitro dissolution tests showed that all the fibers could provide sustained drug release files via a typical Fickian diffusion mechanism. The modified coaxial electrospinning process reported here can expand the capability of electrospinning in generating fibers and provides a new manner for developing novel drug delivery systems.

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Coaxial Electrospinning with Triton X‐100 Solutions as Sheath Fluids for Preparing PAN Nanofibers

Cited by 43 publications

References 43 publications

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

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