Coaxial structured drug loaded dressing combined with induced stem cell differentiation for enhanced wound healing

Gao, Chen; Zhang, Liyuan; Wang, Juan; Cheng, Yue; Chen, Zhongrong; Yang, Runhuai; Zhao, Gang

doi:10.1016/j.msec.2021.112542

Cited by 11 publications

(6 citation statements)

References 47 publications

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“…Magnetic-responsive polymers are typically copolymerized or physically mixed with magnetic nanoparticles. Under the influence of a magnetic field, magnetic-responsive scaffolds exhibit magnetostrictive, magnetothermal, and magnetomotive effects, and/or magnetic-field-induced chemical bond breaking [ 265 , 266 , 267 , 268 ]. These changes result in alterations to the structure, chemical properties, or physical properties of the polymer chains, thus achieving magnetically controlled drug release.…”

Section: Multiresponse Intelligent Drug Delivery Systems Based On Nan...mentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

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Section: Multiresponse Intelligent Drug Delivery Systems Based On Nan...mentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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“…With the aid of magnetothermal effect of MNPs, magnetictriggered drug delivery systems hold great promises in practical applications. Zhao et al [183] developed a core-shell structured magnetic-responsive nanofibrous membrane with PCL/gelatin as shell and Fe 3 O 4 NPs/antibiotic as core components. Owing to magnetothermal effect of Fe 3 O 4 NPs, the type IV collagenase was activated to degrade gelatin in an optimum reaction temperature, resulting in a responsive on-demand drug delivery.…”

Section: Magnetic-triggered Drug Releasementioning

confidence: 99%

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Dong,

Fu,

et al. 2023

Adv Funct Materials

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Smart wound dressings capable of detecting, monitoring, and regulating complicated dynamic healing processes hold tremendous potential in wound healing and tissue reconstruction. Micro/nanofiber‐based materials are regarded as one of the most promising candidates to develop smart wound dressings owing to their remarkable features including architectural mimicry of extracellular matrix, tunability in structural assembly, and diversity in functionality. Herein, the latest progress of smart micro/nanoscale fiber‐based materials in terms of composition engineering, structural design, and applications in wound management is comprehensively reviewed. This work begins with the advances in smart fibers including stimuli‐responsive fibers, shape memory fibers, and conductive fibers. Then, the structural design of fiber‐based materials from conventional 2D fibrous membrane to emerging 3D fibrous sponge/hydrogel is thoroughly discussed. Furthermore, the applications of smart micro/nanofibrous materials as wound dressings in stimuli‐responsive drug delivery, biomechanical stimulation, electrical stimulation, and wound monitoring are highlighted. Finally, the article offers perspectives on the existing challenges and future directions of smart fibrous materials for wound management.

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“…Inappropriate healing of skin wounds impaired by, for example, excessive area/depth, complex tissue damage, or metabolic diseases has the possibility to elicit infections, aggravate injuries, and even cause death. , Additional interventions are needed to promote the wound healing process . Tissue engineering has emerged as a promising approach for skin reconstruction by employing electrospun scaffolds which establish a microenvironment mimicking the extracellular matrices (ECMs) for cell attachment, migration, proliferation, differentiation, and de novo tissue formation. − However, during healing, drastic and abrupt deformations at the wound sites can provoke secondary injuries and cause serious consequences if not perceived in a timely manner. , Since the multifunctional sensing properties of the skin might be diminished or blocked by severe injuries, or the patients are those with incapability of expression, like humans in a vegetative state, the delayed or hindered detection of the secondary injuries are sometimes inevitable. , On this account, wound monitoring is of similar vital importance to wound management, if not more . While various strain sensors have been applied for motion tracking, most of them can only be mounted aside the wounds, which may cause injuries to the vulnerable tissues and even collect inaccurate off-spot signals. , Consequently, the integration of tissue repairing function and the motion tracking capability, viz., the development of strain sensing tissue engineering scaffolds, is desirable and needed for in situ skin reconstruction.…”

Section: Introductionmentioning

confidence: 99%

Highly Elastic and Strain Sensing Corn Protein Electrospun Fibers for Monitoring of Wound Healing

et al. 2023

Self Cite

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Due to the lack of sufficient elasticity and strain sensing capability, protein-based ultrafine fibrous tissue engineering scaffolds, though favorable for skin repair, can hardly fulfill on-spot wound monitoring during healing. Herein, we designed highly elastic corn protein ultrafine fibrous smart scaffolds with a three-layer structure for motion tracking at an unpackaged state. The densely cross-linked protein networks were efficiently established by introducing a highly reactive epoxy and provided the fiber substrates with wide-range stretchability (360% stretching range) and ultrahigh elasticity (99.91% recovery rate) at a wet state. With the assistance of the polydopamine bonding layer, a silver conductive sensing layer was built on the protein fibers and endowed the scaffolds with wide strain sensing range (264%), high sensitivity (gauge factor up to 210.55), short response time (<70 ms), reliable cycling stability, and long-lasting duration (up to 30 days). The unpackaged smart scaffolds could not only support cell growth and accelerate wound closure but also track motions on skin and in vivo and trigger alarms once excessive wound deformations occurred. These features not only confirmed the great potential of these smart scaffolds for applications in tissue reconstruction and wound monitoring but also proved the possibility of employing various plant protein ultrafine fibers as flexible bioelectronics.

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Coaxial structured drug loaded dressing combined with induced stem cell differentiation for enhanced wound healing

Cited by 11 publications

References 47 publications

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings

Highly Elastic and Strain Sensing Corn Protein Electrospun Fibers for Monitoring of Wound Healing

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