Cobaloximes with Pyrazine and Their Dimetallic Complexes

Mandal, Debaprasad; Gupta, B. D.

doi:10.1002/ejic.200600280

Cited by 18 publications

(9 citation statements)

References 53 publications

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“…It is also possible that proteins/enzymes play a role in the reduction of metal ions by the oxidation of benzaldehyde (aldehyde groups) to carboxylic acids. 44,45 A peak at 3,410 cm -1 results from stretching of the amide (N-H) bond of amino groups, and is indicative of bonded -OH groups. The strong absorption peak at 2,920 cm -1 could be assigned to -CH stretching vibrations of -CH 3 and -CH 2 functional groups.…”

mentioning

confidence: 99%

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

Gurunathan¹,

Park²,

Han³

et al. 2015

IJN

275

151

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Background Recently, the use of nanotechnology has been expanding very rapidly in diverse areas of research, such as consumer products, energy, materials, and medicine. This is especially true in the area of nanomedicine, due to physicochemical properties, such as mechanical, chemical, magnetic, optical, and electrical properties, compared with bulk materials. The first goal of this study was to produce silver nanoparticles (AgNPs) using two different biological resources as reducing agents, Bacillus tequilensis and Calocybe indica. The second goal was to investigate the apoptotic potential of the as-prepared AgNPs in breast cancer cells. The final goal was to investigate the role of p53 in the cellular response elicited by AgNPs. Methods The synthesis and characterization of AgNPs were assessed by various analytical techniques, including ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The apoptotic efficiency of AgNPs was confirmed using a series of assays, including cell viability, leakage of lactate dehydrogenase (LDH), production of reactive oxygen species (ROS), DNA fragmentation, mitochondrial membrane potential, and Western blot. Results The absorption spectrum of the yellow AgNPs showed the presence of nanoparticles. XRD and FTIR spectroscopy results confirmed the crystal structure and biomolecules involved in the synthesis of AgNPs. The AgNPs derived from bacteria and fungi showed distinguishable shapes, with an average size of 20 nm. Cell viability assays suggested a dose-dependent toxic effect of AgNPs, which was confirmed by leakage of LDH, activation of ROS, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells in MDA-MB-231 breast cancer cells. Western blot analyses revealed that AgNPs induce cellular apoptosis via activation of p53, p-Erk1/2, and caspase-3 signaling, and downregulation of Bcl-2. Cells pretreated with pifithrin-alpha were protected from p53-mediated AgNPs-induced toxicity. Conclusion We have demonstrated a simple approach for the synthesis of AgNPs using the novel strains B. tequilensis and C. indica , as well as their mechanism of cell death in a p53-dependent manner in MDA-MB-231 human breast cancer cells. The present findings could provide insight for the future development of a suitable anticancer drug, which may lead to the development of novel nanotherapeutic molecules for the treatment of cancers.

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confidence: 99%

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

Gurunathan¹,

Park²,

Han³

et al. 2015

IJN

275

151

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“…Oxime ligands exhibit a notable ability to bridge metal ions [3]. It is well known that the oximate group ( N-O-) can link two metal ions through the imine N-atom and the deprotonated O-atom, thus resulting in the simplest topological types of coordination arrays, polynuclear homo- [4,5] or heterometallic clusters [6-11] and homo- [12,13] or heterometallic [14,15] one-dimensional zigzag chains or one-dimensional helix. Our recent studies on Zn(II) and Cd(II) oxime chemistry aimed for low-dimensional and polymeric materials with wheel-andaxle topology and luminescent properties resulted in the mixed-ligand aggregates where the single charged acetate or formate anions, being coordinated to the metal in a monodentate mode, impose the additional rigidity to the metal-oxime coordination environment through the hydrogen bonding with the neutral oxime hydroxyl groups, while the bidentate bipyridine ligands (4,4′-bipyridine or 1,2-bis(4-pyridyl) ethane) act as spacers between these units giving rise to the binuclear molecules or 1D polymers.…”

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confidence: 99%

Unique tetranuclear heterometallic compound [Na2Zn2{(4-py)C(H)(NOH)}2(CH3COO)6(H2O)4].2H2O with luminescent properties

Coropceanu¹,

Croitor²,

Siminel³

et al. 2011

Inorganic Chemistry Communications

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“…3), respectively. The metal ions have a trans octahedral environment like that found in transition metal complexes of the general formula [MХ(DioxH) 2 A], where X is the halide ion and A is Py, Pz (pyrazine), PPh 3 , and Inia (isonicotinamide) [29][30][31][32][33]. The coordination polyhe dra of the Co 3+ ions in structures I-III are made up of four N atoms of two bidenate monodeprotonated ligands DioxH -, one N atom of the pyrazine ring of Pzca, and the halide ion (Br -or Cl -).…”

Section: Resultsmentioning

confidence: 99%

Asymmetric and symmetric cobalt(III) dioximates with pyrazinecarboxamide: Synthesis and crystal structure

et al. 2012

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461Pyrazinecarboxamide (Pzca) has four electron donating centers and thus can act, depending on the conditions of the synthesis and the complexing metal, as a ligand with different dentate numbers to form mono , di , and polynuclear complexes. Analysis of the Cambridge Crystallographic Data has showed that Pzca in many copper, manganese, vanadyl, mercury, and silver complexes [1-8] is coordinated to the cen tral metal atom through only one N atom of the het erocycle, although its structure contains several elec tron donating centers. However, in terbium, neody mium, and cobalt complexes, as well as in some copper complexes, this organic molecule acts as a bidentate ligand coordinated to the metal atom through the N atom of the heterocycle and the car bamoyl O atom to give mononuclear complexes [9][10][11][12][13][14][15][16]. Pyrazinecarboxamide derivatives additionally functionalized with СONH 2 or СОО -always act as bidentate ligands coordinated either through the same pair of N, O atoms (as, e.g., in copper and nickel com plexes [17][18][19]) or through the electron donating atom of the substituent [20]. Mononuclear complexes of transition metals with Pzca can have the metal : Pzca ratios of 1 : 1 [1, 6, 17, 19] and 1 : 2 [2, 3, 5, 7, 11-16], regardless of the mono or bidentate coordi nation of Pzca. In Nd and Tb complexes, three such ligands are coordinated in a bidentate fashion to one metal atom, through more than two electron donating centers. Pyrazinecarboxamide acts as a bridging ligand in copper and silver complexes using a set of N,N,O atoms to form a polynuclear structure. One Pzca ligand can be coordinated to two metal atoms [21][22][23] (being bidentate with respect to one and monodentate with respect to the other) or to three metal atoms in a monodentate fashion as in a silver complex [24].When analyzing the Cambridge Crystallographic Data, we have found several crystallographic studies of metal complexes combining Pzca and other organic ligands [4,8,16,22]. However, data on complexes of transition metal dioximates with Pzca are lacking. To reveal the way in which Pzca is coordinated to the cen tral metal ion, the specific features of the coordination polyhedron of Co(III), and the relative positions and crystal packing of the complexes, we obtained four dif ferent complexes all combining dioxime (DioxH) resi due and Pzca. Three of the complexes were identified by X ray diffraction:[CoCl(NioxH) 2 (Pzca)] (II), and [CoCl(DmgH)(NioxH)(Pzca)] ⋅ 0.5C 2 H 5 OH ⋅ 0.5Н 2 О (III), where DmgH, DfgH, and NioxH are the monoanions of dimethylglyoxime, diphenylglyoxime, and cyclohexane 1,2 dione dioxime, respectively. Complexes I and II contain only one type of the dioxime (DfgH or NioxH), while asymmetric com plex III contains the residues of different dioximes (DmgH and NioxH). We also obtained a symmetric Co(III) complex with DmgH and Pzca, viz., [CoCl(DmgH) 2 (Pzса)] (IV). Complexes I-IV were examined by elemental analysis and IR spectroscopy. Abstract-A number of novel complexes of cobalt(III) trans dioxim...

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Cobaloximes with Pyrazine and Their Dimetallic Complexes

Cited by 18 publications

References 53 publications

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

Unique tetranuclear heterometallic compound [Na2Zn2{(4-py)C(H)(NOH)}2(CH3COO)6(H2O)4].2H2O with luminescent properties

Asymmetric and symmetric cobalt(III) dioximates with pyrazinecarboxamide: Synthesis and crystal structure

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Cobaloximes with Pyrazine and Their Dimetallic Complexes

Cited by 18 publications

References 53 publications

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in&nbsp;MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in&nbsp;MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

Unique tetranuclear heterometallic compound [Na2Zn2{(4-py)C(H)(NOH)}2(CH3COO)6(H2O)4].2H2O with luminescent properties

Asymmetric and symmetric cobalt(III) dioximates with pyrazinecarboxamide: Synthesis and crystal structure

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Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy