Cobalt‐Catalyzed C(sp³)−H Functionalization Reactions

Abstract

C−H functionalization reactions hold great potential for the streamlined synthesis of complex molecules and are currently a “hot” topic in organic synthesis. Among the various transition metals that have been used, cobalt has recently attracted increased attention as a catalyst for C−H functionalization reactions, owing to its ready availability and high reactivity. Although a number of cobalt‐catalyzed C(sp2)−H functionalization reactions have been reported to date, C(sp3)−H functionalization reactions remain challenging. This Focus Review summarizes recent progress in cobalt‐catalyzed C(sp3)−H functionalization reactions that involve C−H activation to form organometallic intermediates.

Catalytic addition of C–H bonds across C–C unsaturated systems promoted by iridium(i) and its group IX congeners

“…Curiously, despite the efficiency of these and related cobalt(I)catalysts for promoting C(sp 3 )-H bond activations, 92 their application to hydrocarbonation reactions (formation of C-C bonds)…”

“…Linear-selective alkene insertion into the Ir-H bond forms III. Eventually an irreversible C(sp 3 )-C(sp 3 ) reductive elimination and protonation of the amine affords the alkylated urea product (92).…”

Metallaphotoredox-catalyzed C–H activation: regio-selective annulation of allenes with benzamide

“…Recently, low-cost and earth-abundant rst-row transition metals seem to be an appealing alternative to noble metals [7][8][9][10]. Among the rst-row transition metals, the unique properties of cobalt in varied oxidation states have witnessed the powerful ability to manipulate various chemical bonds as a result of the chelation-assisted direct metalation of azobenzene [11][12][13][14][15][16]. Among such elegant transformations, a number of C − H activation and oxidative annulation reactions with various unsaturated coupling partners, such as alkynes and alkenes, have garnered considerable attention for molecule diversity in step-and atom-economical strategies [17].…”

Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with Bis-Pyrazolo-S-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities

“…In this aspect, the triazine class [10][11][12][13][14][15][16][17][18][19] and their metal complexes [20][21][22][23][24] have been received a great deal of attention as they demonstrate wide range of therapeutic activities and a great array of biological applications including antimicrobial, antituberculosis, anticancer, antiviral, antibacterial, antifungal, anti-HIV, and antimalarial activities [9,25,26]. In addition, a number of metal complexes based on triazine derivatives have been studied for their interesting magnetic [27][28][29] and catalytic [30][31][32][33][34][35][36][37][38][39][40][41] applications. antibacterial, antifungal, anti-HIV, and antimalarial activities [9,25,26].…”

“…antibacterial, antifungal, anti-HIV, and antimalarial activities [9,25,26]. In ad number of metal complexes based on triazine derivatives have been studied interesting magnetic [27][28][29] and catalytic [30][31][32][33][34][35][36][37][38][39][40][41] applications.…”