Cobalt‐Catalyzed Diastereo‐ and Enantioselective Hydroarylation of Cyclopropenes with Arylboronic Acids

Abstract

Catalytic diastereo‐ and enantioselective hydroarylation of 3,3‐disubstituted cyclopropenes with easily accessible arylboronic acids promoted by a chiral phosphine‐Co complex is presented. Such a process represents an unprecedented Co‐catalyzed approach for direct introduction of a variety of aryl groups onto the cyclopropane motif, affording multisubstituted cyclopropanes in up to 86% yield with greater than 95 : 5 dr and 99 : 1 er.

Chiral bisphosphine Ph-BPE ligand: a rising star in asymmetric synthesis

“…94 Recently, Meng et al have reported the arylation of 3,3-disubstituted cyclopropenes (Scheme 25b). 95 The introduction of various aryl groups onto the cyclopropane motif resulted in the formation of multi-substituted cyclopropanes with a yield of up to 86%. These cyclopropanes displayed a dr value greater than 95 : 5 and an ee value up to 98%.…”