2024
DOI: 10.1002/ange.202316021
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Cobalt‐Catalyzed Enantio‐ and Regioselective C(sp3)−H Alkenylation of Thioamides

Lucia Staronova,
Ken Yamazaki,
Xing Xu
et al.

Abstract: An enantioselective cobalt‐catalyzed C(sp3)–H alkenylation of thioamides with but‐2‐ynoate ester coupling partners employing thioamide directing groups is presented. The method is operationally simple and requires only mild reaction conditions, while providing alkenylated products as single regioisomers in excellent yields (up to 85%) and high enantiomeric excess [up to 91:9 enantiomeric ratio (er), or up to >99:1 er after a single recrystallization]. Diverse downstream derivatizations of the products are d… Show more

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