2022
DOI: 10.1002/ange.202213913
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Cobalt‐Catalyzed Enantioselective Hydroamination of Arylalkenes with Secondary Amines

Abstract: Catalytic asymmetric hydroamination of alkenes with Lewis basic amines is of great interest but remains a challenge in synthetic chemistry. Here, we developed a Co-catalyzed asymmetric hydroamination of arylalkenes directly using commercially accessible secondary amines. This process enables the efficient access to valuable α-chiral tertiary amines in good to excellent yields and enantioselectivities. Mechanistic studies suggest that the reaction includes a CoHmediated hydrogen atom transfer (MHAT) with arylal… Show more

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