Cobalt-Catalyzed Three-Component Alkyl Arylation of Acrylates with Alkyl Iodides and Aryl Grignard Reagents

Abstract

A highly regioselective cobalt-catalyzed three-component alkyl arylation of acrylates with alkyl iodides and aryl Grignard reagents has been established. The reaction efficiently provides an alternative strategy for the construction of α-aryl esters with a broad substrate scope and good yields under mild conditions. The practical applicability of this protocol is shown by the scaled-up reaction and further transformations of the products. In addition, the preliminary mechanistic explorations demonstrated that the alkyl radicals generated by the efficient cobalt catalysis are instantaneously added to the acrylates to finally afford the desired products.