Cobalt derivatives of Schiff bases of aliphatic amines as antitumor agents

Control of heme metabolism with synthetic metalloporphyrins.

“…The major sites, in the liver, at which such perturbations in heme metabolism take place are at the levels of -aminolevulinic acid (ALA)' synthase and heme oxygenase (the rate-controlling enzymes in the synthesis of heme and in its catabolism to bile pigments, respectively) and at the formation and function of cytochrome(s) P-450, the family of monooxygenases which catalyzes the oxidative metabolism of numerous, structurally diverse, natural and foreign chemicals (2,3 (21,22), while tin, in various organic forms, is now being widely employed as a biocidal agent for agricultural purposes (23,24), a use which carries the potential of substantial human exposure to the compound. In examining the actions oforganic tin compounds on heme oxygenase, it became apparent that organification of the metal not only shifted the tissue site of action ofthe contained element from kidney (16) to liver (25,26), a fact of considerable toxicological importance, but that it also greatly prolonged the enzyme-inducing action ofthe metal; for example, heme oxygenase induction persisted as long as 10 d after a single dose of an organotin compound.…”

Crystal structure of 2-[1-(2-chlorophenyl)-methylidene]hydrazino-1-(3,4- dihydroxyphenyl)ethanone monohydrate, C14H11ClN2O3 · H2O

“…These compounds play an important role in the development of coordination chemistry [1][2][3]. Some of the complexes derived from Schiff bases have been found to have pharmacological potential and antitumor activity [4][5][6]. Recently, we have reported a few Schiff base compounds [7][8][9].…”

Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone

“…In addition to their magnetic and photophysical properties, the bioactivities of Lns, including their antimicrobial, antitumor, antivirus and anticoagulant action, as well as their ability to prevent arteriosclerosis, have been explored in recent decades (16)(17)(18)(19).…”