Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing

Chen, Xiaodong; He, Shuohan; Dong, Yilong; Chen, Maohua; Xia, Zengzilu; Cai, Kaiyong; Hu, Yan

doi:10.1016/j.mtbio.2023.100912

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…When investigating the effect of surface morphology on angiogenesis, implants with porous macrostructures and nano microstructures have considerably impacted the coupling of angiogenesis and osteogenesis. The 3D-printed porous Ti6Al4 V scaffolds − exhibit similar mechanical properties to those of natural bone, which reduces stress shielding and increases the contact area between the Ti implant ,− and the surrounding bone to promote osteoblast adhesion and the growth of nerves and blood vessels. − Angiogenesis can also be stimulated by forming nanomorphologies on Ti implant surfaces via modification methods, such as rutile nanorods, disordered TiO 2 nanorods with magnetic properties, acid-etched Ti surfaces modified with zinc-containing nanowires, and 3D-printed Ti6Al4 V scaffolds containing UiO-66 nanocrystals …”

Section: Static Modification Strategymentioning

confidence: 99%

“…Magnetron sputtering has been widely used for the deposition of thin films of metals and compounds . Strontium in addition to exerting anti-inflammatory effects has also been shown to increase the expression of vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells (HUVECs) and activate the ERK1/2 signaling pathway to promote angiogenesis. , Magnesium is biologically active and is involved in the angiogenesis. , A magnesium coating can be deposited on porous Ti6Al4 V scaffolds via sputtering . Such scaffolds can considerably enhance the proliferation, adhesion, and Transwell capacity of HUVECs, as well as increase the expression of angiogenesis-related genes.…”

Section: Static Modification Strategymentioning

confidence: 99%

“…92,93 Magnesium is biologically active and is involved in the angiogenesis. 94,95 A magnesium coating can be deposited on porous Ti6Al4 V scaffolds via sputtering. 79 Such scaffolds can considerably enhance the proliferation, adhesion, and Transwell capacity of HUVECs, as well as increase the expression of angiogenesis-related genes.…”

Section: T H I S C O N T E N T Imentioning

confidence: 99%

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The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

Cui,

Zhao,

Bai

et al. 2024

ACS Biomater. Sci. Eng.

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Titanium (Ti) and its alloys are widely used biomaterials in bone repair. Although these biomaterials possess stable properties and good biocompatibility, the high elastic modulus and low surface activity of Ti implants have often been associated with infection, inflammation, and poor osteogenesis. Therefore, there is an urgent need to modify the surface of Ti implants, where changes in surface morphology or coatings loading can confer specific functions to help them adapt to the osseointegration formation phase and resist bacterial infection. This can further ensure a healthy microenvironment for bone regeneration as well as the promotion of immunomodulation, angiogenesis, and osteogenesis. Therefore, in this review, we evaluated various functional Ti implants after surface modification, both in terms of static modifications and dynamic response strategies, mainly focusing on the synergistic effects of antimicrobial activities and functionalized osteogenic. Finally, the current challenges and future perspectives are summarized to provide innovative and effective solutions for osseointegration and bone defect repair.

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Section: Static Modification Strategymentioning

confidence: 99%

Section: Static Modification Strategymentioning

confidence: 99%

Section: T H I S C O N T E N T Imentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

Cui,

Zhao,

Bai

et al. 2024

ACS Biomater. Sci. Eng.

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Visible Light‐Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility

Maleki‐Ghaleh,

Kamiński,

Moradpur‐Tari

et al. 2024

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Cutting‐edge research in advanced materials is increasingly turning toward the development of novel multifunctional nanomaterials for use in high‐tech applications. This research uses the solid‐state method as a solvent‐free technique to create multifunctional quantum dot (QD) hydroxyapatite (HA) crystals from bovine bone waste. By incorporating cobalt (Co) and magnesium (Mg) into the HA structure, the crystallinity of the hexagonal HA nanoparticles (99.7%), showing QD crystals is enhanced. Oxygen vacancies on the surfaces of the HA nanoparticles contributed to their bandgap falling within the visible light range. In addition, the dopants substituted calcium in the HA crystal structure and generated a divalent oxidation state, shifting the bandgap of natural HA toward red wavelengths (3.26 to 1.94 eV). Moreover, the incorporation of Co led to magnetization within the HA structure through spin polarization. Additionally, the doped QD crystals of HA nanoparticles showed significant antimicrobial activity against Escherichia coli, Staphylococcus aureus, and bacteriophages MS2, particularly under visible light exposure. In short, the Co/Mg co‐doped HA nanoparticles exhibited ferromagnetic properties, sensitivity to visible light, biocompatibility, and considerable antimicrobial effects, establishing their potential as sustainable multifunctional materials for biomedical applications, especially in anti‐infection treatments.

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Multidimensional treatment of periprosthetic joint infection using fusion peptide-grafted chitosan coated porous tantalum scaffold

Liu,

Zhang,

Sun

et al. 2025

Bioactive Materials

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Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing

Cited by 4 publications

References 67 publications

The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

Visible Light‐Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility

Multidimensional treatment of periprosthetic joint infection using fusion peptide-grafted chitosan coated porous tantalum scaffold

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