2024
DOI: 10.1021/acscatal.4c02211
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Cobalt Hydride-Catalyzed Hydroalkynylation of Alkenes with Alkynyl Trifluoroborates

Meihui Guan,
Ting Yin,
Yue Wang
et al.

Abstract: A cobalt-catalyzed hydroalkynylation of alkenes with alkynyl trifluoroborates is described, proceeding through a cobalt hydride-mediated radical-polar crossover metal hydrogenatom-transfer process. This method affords structurally diverse alkynyl-containing compounds in high yields under mild conditions and features a wide substrate scope, good functional group tolerance, and suitability for late-stage functionalization of relatively complex natural products and bioactive molecules. Expanding the scope to alke… Show more

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