Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression

Xu, Jing; Yang, Junyao; Nyga, Agata; Ehteramyan, Mazdak; Moraga, Ana; Wu, Yuanhao; Zeng, Lingfang; Knight, Martin M.; Shelton, Julia C.

doi:10.1016/j.actbio.2018.03.054

Cited by 50 publications

(28 citation statements)

References 60 publications

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“…The significant correlation of MRI off‐resonance frequency density with the necrosis grades shown in Table 4 is supportive of the proposed hypothesis on the clinical significance of Co over Cr ion concentrations in THA. This observation is also supported by recent pathological study findings by Xu et al, 31 which demonstrated that Co, rather than Cr, has a distinctive pathogenesis signature causing macrophage retention by restructuring the cytoskeleton and inhibiting cell migration via reactive oxygen species production that affects Rho family GTPase.…”

Section: Discussionsupporting

confidence: 81%

Multivariate use of MRI biomarkers to classify histologically confirmed necrosis in symptomatic total hip arthroplasty

Sherafati

Bauer

Potter

et al. 2020

Journal Orthopaedic Research

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The failure of total hip arthroplasty (THA) is commonly associated with the necrosis of the periprosthetic tissue. To date, there is no established method to noninvasively quantify the progression of such necrosis. Magnetic resonance imaging (MRI) of soft tissues near implants has undergone a recent renaissance due to the development of multispectral metal‐artifact reduction techniques. Advanced analysis of multispectral MRI has been shown capable of detecting small magnetism effects of metallic debris in periprosthetic tissue. The purpose of this study is to demonstrate the diagnostic utility of these MRI‐based tissue‐magnetism signatures. Together with morphological MRI metrics, such as synovial volume and thickness, these measurements are utilized as biomarkers to noninvasively detect soft‐tissue necrosis in symptomatic THA patients (N=78). All subjects underwent an advanced MRI scan before revision surgery and tissue biopsies utilized for necrosis grading. Statistical analyses demonstrated a weak, but significant positive correlation (P = .04) between MRI magnetism signatures and necrosis scores, while indicating no meaningful association between the latter and serum cobalt and chromium ion levels. Receiver‐operating characteristic (ROC) analyses were then performed based on uni‐ and multivariate logistic regression models utilizing the measured MRI biomarkers as predictors of severe necrosis. The area under the curve of the ROC plots for MRI biomarkers as combined predictors were found to be 0.70 and 0.84 for cross‐validation and precision‐recall tests, respectively.

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Section: Discussionsupporting

confidence: 81%

Multivariate use of MRI biomarkers to classify histologically confirmed necrosis in symptomatic total hip arthroplasty

Sherafati

Bauer

Potter

et al. 2020

Journal Orthopaedic Research

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“…Studies have shown that Co(II), Ni(II) and Cr(III) can significantly reduce cell vitality and cause pathological changes such as cell contraction, shedding, vacuole and swelling, apoptotic cells increased mostly in Co(II) exposure, and cell necrosis was predominant in Ni(II) exposure [53][54][55][56]. Co(II) can significantly reduce the movement ability of macrophages and inhibit cell migration by RhoA downregulation and cytoskeleton reorganization, which is still happened by the emergence of ROS [57]. Ni ions gradually accumulated in cells also affect the ability of bone morphogenetic protein (BMP-2) to induce alkaline phosphatase (ALP) formation [58,59].…”

Section: Different Metal Ions Can Induce Cell Damagementioning

confidence: 99%

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

Li¹,

Yao²,

Zhang³

et al. 2020

SN Appl. Sci.

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Repair, reconstruction, and replacement of congenital malformations, either in case of exogenous or iatrogenic tissue and organ defects, requires utilization of a large number of personalized biomaterials. In recent decades, the improvement of people's quality of life and the prolongation of life expectancy have promoted the development of medical and material science. In addition to the traditionally used stainless steel, other materials such as cobalt-chromium alloy, pure titanium, titanium alloy, and the newly alloy materials continue to emerge, such as tantalum-based alloy materials which have been used in clinic, especially the application of porous tantalum trabecular metal in orthopedics. This paper which has provided good preliminary works for the development of tantalum biomaterials with more advantages in the future such as tantalum dental implants summarizes in detail the progress of tantalum materials in physicochemical properties and biocompatibility in recent years. From the comparison of surface passivation films of different metals in different environments, the electrochemical corrosion behavior of tantalum, the release of different metal ions and the damage to cells, it is concluded that tantalum has excellent corrosion resistance. Besides, the excellent biocompatibility of tantalum metals concluded by cytology, molecular biology, protein adsorption experiment, and hematology experiment, as well as regular follow-up observation of patients with porous tantalum trabecular metal in clinic. The excellent corrosion resistance and biocompatibility of the tantalum metal have a very wide prospect in clinical application.

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“…radicals through a Fenton-like reaction and produce a large number of reactive oxygen species (ROS) [12]. Oxidative stress is found to be one of the key mechanisms of cobalt cytotoxicity [1,[13][14][15][16][17]. However, the molecular mechanism of oxidative stress-induced cell death of CoNPs remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death

Liu

Zhu

et al. 2020

J Nanobiotechnol

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As a main element in the hard metal industry, cobalt is one of the major components of human metal implants. Cobalt-containing implants, especially joint prostheses used for artificial joint replacement, can be corroded due to the complex physiological environment in vivo, producing a large number of nanoscale cobalt particles (Cobalt Nanoparticles, CoNPs). These CoNPs can be first accumulated around the implant to cause adverse local reactions and then enter into the blood vessels followed by reaching the liver, heart, brain, kidney, and other organs through systematic circulation, which leads to multi-system toxicity symptoms. To ensure the long-term existence of cobalt-containing implants in the body, it is urgently required to find out a safe and effective detoxification drug. Herein, we have demonstrated that CoNPs could induce the ferroptosis-like cell death through the enhancement of intracellular reactive oxygen species (ROS) level, cytoplasmic Fe2+ level, lipid peroxidation, and consumption of reduced glutathione (GSH) as well as inhibition of glutathione peroxidase 4 (GPX4) activity. Importantly, α-lipoic acid (ALA), a natural antioxidant with the capability to scavenge free radicals and chelate toxic metals, was found to efficiently alleviate the adverse effects of CoNPs. The present study illustrates a new mechanism of CoNPs mediated by ferroptosis-like cytotoxicity and discloses an effective method for the detoxification of CoNPs by employing the natural antioxidant of ALA, providing a basis for further in vivo detoxification study.

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Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression

Abstract: Graphical abstract

Cited by 50 publications

References 60 publications

Multivariate use of MRI biomarkers to classify histologically confirmed necrosis in symptomatic total hip arthroplasty

Multivariate use of MRI biomarkers to classify histologically confirmed necrosis in symptomatic total hip arthroplasty

The progress on physicochemical properties and biocompatibility of tantalum-based metal bone implants

Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death

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