Cobalt(II), nickel(II), palladium(II) and zinc(II) metallothiosemicarbazones: Synthesis, characterization, X-ray structures and biological activity

Çakmakçı, Ece Su; Subaşı, Elif; Öztürk, Emine; Şahiner, A.; Yüksel, Betül Şen

doi:10.1016/j.ica.2023.121462

Cited by 5 publications

(2 citation statements)

References 65 publications

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“…The results show that, among the complexes whose activities were detected, there is no finding that reduces the activity of the T1 ligand, while some complexes increase the activity. The same situation is observed in disk diffusion analysis, except for the activity of the Ni(II) complex (T4) against C. albicans [17]. [17] In another study, Sharma et al synthesized semicarbazone and thiosemicarbazone Schiff bases from symmetrical chalcones (Figure 3).…”

Section: Antimicrobial Activities Of Thiosemicarbazonessupporting

confidence: 55%

“…The same situation is observed in disk diffusion analysis, except for the activity of the Ni(II) complex (T4) against C. albicans [17]. [17] In another study, Sharma et al synthesized semicarbazone and thiosemicarbazone Schiff bases from symmetrical chalcones (Figure 3). They investigated the antimicrobial activities of the compounds against one gram-negative Escherichia coli MTCC42 and one gram-positive bacteria Bacillus subtilis MTCC736 using the agar well diffusion method.…”

Section: Antimicrobial Activities Of Thiosemicarbazonessupporting

confidence: 55%

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A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds

Korkmaz

2024

Journal of New Results in Science

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Thiosemicarbazones can be synthesized by condensation of thiosemicarbazides with ketones or aldehydes and play a role as precursors in the synthesis of many compounds such as thiazoles. They can exhibit many biological activities such as anti-inflammatory, antitumor, and antimicrobial properties. The discovery of antibiotics was an important milestone in the treatment of bacterial infections. However, antimicrobial resistance developed by microorganisms has created the need to discover new antimicrobial agents. Thiosemicarbazones and thiosemicarbazone-based compounds show significant antimicrobial potential. This review investigates the antimicrobial activity results of 244 Thiosemicarbazones and Thiosemicarbazone-based compounds over the last five years. We summarized some articles on thiosemicarbazones and their hybrids showing only antibacterial and antifungal activity in Web of Science (WOS) between 2019 and 2024.

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Section: Antimicrobial Activities Of Thiosemicarbazonessupporting

confidence: 55%

Section: Antimicrobial Activities Of Thiosemicarbazonessupporting

confidence: 55%

A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds

Korkmaz

2024

Journal of New Results in Science

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Synthesis, Structural Investigations, and Potential Antimicrobial and Anticancer Activity of Mononuclear Zn(II) and Cd(II) Complexes Decorated by Morpholine/Pyrazole s‐Triazine Ligand

Gad,

Altowyan,

Abu‐Youssef

et al. 2024

Applied Organom Chemis

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The structure and biological diversities of [Zn(BPTMorph)(H2O)3](ClO4)2 (1), [Zn(BPTMorph)(NO3)2] (2), and [Cd(BPTMorph)(NO3)2] (3) complexes were described. In all complexes, the Zn(II) and Cd(II) ions are coordinated with one 4‐(4,6‐bis(3,5‐dimethyl‐1H‐pyrazol‐1‐yl)‐1,3,5‐triazin‐2‐yl)morpholine (BPTMorph) molecule as a pincer NNN‐chelate. The rest of the coordination sphere was found to depend on the type of anion. In 1, there are three coordinated water molecules leading to a distorted octahedral geometry around Zn(II). In 2 and 3, there are two coordinated NO3− groups that differ in their coordination modes. The two NO3− groups are monodentate in 1 and bidentate in 3. Hence, the coordination numbers of Zn(II) and Cd(II) are 5 and 7, respectively. Supramolecular structure investigations indicated the importance of O···H contacts in the molecular packing. The percentages of O···H contacts are 35.4%–36.1%, 44.8%, and 39.7% in complexes 1–3, respectively. The energy breakdown for the intermolecular interactions was performed using energy framework analysis to explore the forces that dominate these interactions. Anticancer activity of complexes 1–3 and BPTMorph against HepG‐2, MCF‐7, and A‐549 cancerous cells was presented. The best result is found for complex 3 against A‐549 where the IC50 is 2.77 ± 0.26 μg/mL and selectivity index is 12.5 although the corresponding values for BPTMorph are 32.39 ± 2.82 μg/mL and 2.7, respectively. In addition, 3 outperformed the anticancer drug cis‐platin against all cell lines. The antimicrobial activity of 3 is the best compared to 1, 2, and BPTMorph. Interestingly, 3 showed antibacterial efficiency comparable to gentamycin against Proteus vulgaris.

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Crystal structure, optical, magnetic and antibacterial properties of a new tetrachlorocobaltate(II) salt with 4-nitrobenzyl substituted 2-methyl pyridinium

Jiang,

Wen,

Zheng

et al. 2024

Journal of Molecular Structure

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Cobalt(II), nickel(II), palladium(II) and zinc(II) metallothiosemicarbazones: Synthesis, characterization, X-ray structures and biological activity

Cited by 5 publications

References 65 publications

A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds

A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds

Synthesis, Structural Investigations, and Potential Antimicrobial and Anticancer Activity of Mononuclear Zn(II) and Cd(II) Complexes Decorated by Morpholine/Pyrazole s‐Triazine Ligand

Crystal structure, optical, magnetic and antibacterial properties of a new tetrachlorocobaltate(II) salt with 4-nitrobenzyl substituted 2-methyl pyridinium

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