2012
DOI: 10.5012/bkcs.2012.33.8.2762
|View full text |Cite
|
Sign up to set email alerts
|

Cobalt (III) Complexes as Novel Matrix Metalloproteinase-9 Inhibitors

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2014
2014
2022
2022

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(1 citation statement)
references
References 18 publications
0
1
0
Order By: Relevance
“…The ligands bound to the metal center sometime play an important role in the inhibition properties of the MC. For example, [Co(acacen)(NH 3 ) 2 ]Cl, 44 a complex with two substitutionally labile trans ammonia ligands, is almost ten times more potent as an inhibitor of MMP-9 than [Co(acacen)(Im) 2 ]Cl, an analogous complex containing the substitutionally less labile imidazole ligands (Im). The binding of coordinating residues of the protein to the Co center must play a role in this case.…”
Section: Metal Complexes As Metalloprotease Inhibitorsmentioning
confidence: 99%
“…The ligands bound to the metal center sometime play an important role in the inhibition properties of the MC. For example, [Co(acacen)(NH 3 ) 2 ]Cl, 44 a complex with two substitutionally labile trans ammonia ligands, is almost ten times more potent as an inhibitor of MMP-9 than [Co(acacen)(Im) 2 ]Cl, an analogous complex containing the substitutionally less labile imidazole ligands (Im). The binding of coordinating residues of the protein to the Co center must play a role in this case.…”
Section: Metal Complexes As Metalloprotease Inhibitorsmentioning
confidence: 99%