Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice

Ton, Thai-Vu; Kovi, Ramesh C.; Peddada, Teja; Chhabria, Raveena M; Shockley, Keith R.; Flagler, Norris; Gerrish, Kevin; Herbert, Ronald A.; Behl, Mamta; Hoenerhoff, Mark J.; Sills, Robert C.; Pandiri, Arun R.

doi:10.1007/s00204-021-03146-5

Cited by 6 publications

(3 citation statements)

References 109 publications

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“…Alveolar/bronchiolar carcinomas in rodents, whether occurring spontaneously or due to chemical exposure, bear resemblance to a specific subtype of lung adenocarcinomas observed in humans. Oxidative stress is a key factor in pulmonary carcinogenesis induced by cobalt metal dust (CMD) in rodents, and these discoveries may have implications for understanding human lung cancers as well [54]. The impact of CoCl2 was also examined on numerous histone modifications at a global level.…”

Section: Cobaltmentioning

confidence: 99%

Assessment of the Impact of Trace Essential Metals on Cancer Development

Górska,

Markiewicz-Gospodarek,

Trubalski

et al. 2024

IJMS

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This study examines the impact of zinc, copper, cobalt, iron, and manganese on cancer development, considering their dual roles as potential promoters or inhibitors within tumorigenesis. A comprehensive analysis of existing literature and experimental data is conducted to elucidate the intricate relationship between these trace elements and cancer progression. The findings highlight the multifaceted effects of zinc, copper, cobalt, iron, and manganese on various aspects of cancer development, including cell proliferation, angiogenesis, and metastasis. Understanding the nuanced interactions between these trace elements and cancer could offer crucial insights into tumorigenesis mechanisms and facilitate the identification of novel biomarkers and therapeutic targets for cancer prevention and treatment strategies. This research underscores the importance of considering the roles of essential trace elements in cancer biology and may ultimately contribute to advancements in precision medicine approaches for combating cancer.

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Section: Cobaltmentioning

confidence: 99%

Assessment of the Impact of Trace Essential Metals on Cancer Development

Górska,

Markiewicz-Gospodarek,

Trubalski

et al. 2024

IJMS

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Section: Introductionmentioning

confidence: 99%

“…For example, G to T transversions in codon 12 of Kras gene are commonly noted in lung cancers resulting from tobacco smoke exposure and also in rodent lung tumors resulting from chronic exposure to cobalt, which is mechanistically attributed to metal-induced oxidative stress. 9,10 In human non-small-cell lung cancer (NSCLC), the incidence of Kras mutations is approximately 26%, with the majority of the point mutations seen in codon 12 followed by fewer mutations in codons 13 and 61. 5,11 Point mutations in codons 12, 13, and 61 of Kras are activating mutations that result in constitutive activation of the KRAS protein, making it refractory to the inhibitory GTPase-activating proteins, which results in stimulus-independent, persistent activation of downstream effectors, in particular, the RAF-MEK-ERK cascade.…”

Section: Introductionmentioning

confidence: 99%

Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice

et al. 2023

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Antimony trioxide (AT) is used as a flame retardant in fabrics and plastics. Occupational exposure in miners and smelters is mainly through inhalation and dermal contact. Chronic inhalation exposure to AT particulates in B6C3F1/N mice and Wistar Han rats resulted in increased incidences and tumor multiplicities of alveolar/bronchiolar carcinomas (ABCs). In this study, we demonstrated Kras (43%) and Egfr (46%) hotspot mutations in mouse lung tumors (n = 80) and only Egfr (50%) mutations in rat lung tumors (n = 26). Interestingly, there were no differences in the incidences of these mutations in ABCs from rats and mice at exposure concentrations that did and did not exceed the pulmonary overload threshold. There was increased expression of p44/42 mitogen-activated protein kinase (MAPK) (Erk1/2) protein in ABCs harboring mutations in Kras and/or Egfr, confirming the activation of MAPK signaling. Transcriptomic analysis indicated significant alterations in MAPK signaling such as ephrin receptor signaling and signaling by Rho-family GTPases in AT-exposed ABCs. In addition, there was significant overlap between transcriptomic data from mouse ABCs due to AT exposure and human pulmonary adenocarcinoma data. Collectively, these data suggest chronic AT exposure exacerbates MAPK signaling in ABCs and, thus, may be translationally relevant to human lung cancers.

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Morpho-physiological and Biochemical Effects of Palm Pollen Extract in Alleviation of Cadmium and Cobalt Toxicity in Beans (Phaseolus vulgaris L.)

Nessem

Ebrahim

Saad‐Allah

et al. 2023

J Soil Sci Plant Nutr

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Palm pollen extract (PPE) is a viable source of osmoregulators, phytohormones, vitamins, minerals, enzymes, and cofactors supporting plant growth in normal and challenging environments. In this study, we explored the competency of methanolic-aqueous PPE to amend cadmium (Cd) and cobalt (Co) toxicity in beans (Phaseolus vulgaris L.). Bean seeds were germinated in clay-sandy soil containing plastic containers, thinned, and then administered 50 mM CdCl2, CoCl2, or a combination of both. Treated seedlings were foliar sprayed with PPE or distilled water (10 ml PPE pot-1). To assess their response, seedlings were harvested at 21 days old. Cd and Co, individually or combined, impaired beans growth, chlorophyll content, soluble sugars, amino acids, ascorbate peroxidase (APX), peroxidase (POD), glutathione reductase (GR) activities, flavonoids, macronutrients (N, P, and K), and yield components, particularly when combined. Metal treatments, however, upraised electrolyte leakage and catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST) activities, beside increasing carotenoids, proline, hydrogen peroxide (H2O2), malondialdehyde (MDA), and phenolic levels. However, PPE contributed to lessening Cd and Co toxicity by restoring the growth, chlorophyll concentration, membrane stability, metabolic activity, and redox and ionic equilibrium. Moreover, PPE restored the metal-induced declines in carotenoids, flavonoids, antioxidant potential, and grain yield. PPE played a valuable role in metal-stressed beans by increasing proteins, amino acids, and phenols; improving APX, POD, and GST activities; and decreasing Cd and Co uptake. Overall, PPE could be employed as a feasible approach to support Cd- and Co-stressed bean growth, photosynthetic activity, osmotic and ionic homeostasis, and yield performance.

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Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice

Cited by 6 publications

References 109 publications

Assessment of the Impact of Trace Essential Metals on Cancer Development

Assessment of the Impact of Trace Essential Metals on Cancer Development

Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice

Morpho-physiological and Biochemical Effects of Palm Pollen Extract in Alleviation of Cadmium and Cobalt Toxicity in Beans (Phaseolus vulgaris L.)

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