Cobalt Metal Inhalation Studies on Miniature Swine

Kerfoot, E.J.; Fredrick, William G.; Domeier, Edward

doi:10.1080/0002889758507202

Cited by 65 publications

(26 citation statements)

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“…Since the first recognition of adverse health effects from WC-Co exposure in the 1960s (Trautmann, 1958; Bech et al , 1962; Heuer, 1962; Beritic et al , 1963; Joseph, 1968), there have been a number of reports regarding the toxicity of WC-Co in the literature both in vitro (Edel et al , 1990; Lison and Lauwerys, 1990; Lison and Lauwerys, 1992; Lison and Lauwerys, 1993; Lison et al , 1995; Anard et al , 1997; Antonini et al , 2000; Roesems et al , 2000; Fedan and Cutler, 2001; De Boeck et al , 2003b; Lombaert et al , 2008; Bastian et al , 2009; Ding et al , 2009; Kuhnel et al , 2009; Busch et al , 2010; Zhang et al , 2010; Lombaert et al , 2012) and in vivo (Kerfoot et al , 1975; Kitamura et al , 1980; Lasfargues et al , 1992; Huaux et al , 1995; Lasfargues et al , 1995; Adamis et al , 1997; Rengasamy et al , 1999; De Boeck et al , 2003a). While it is well established that composite WC-Co particles are more toxic than tungsten (W), tungsten carbide (WC) or cobalt (Co) alone, the potential contribution of WC-Co particle internalization toward observed toxicity and the mechanism by which WC-Co particles could be internalized by relevant cells has not been well-addressed.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

Armstead

Arena

2014

Toxicology and Applied Pharmacology

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Tungsten carbide cobalt (WC-Co) has been recognized as a workplace inhalation hazard in the manufacturing, mining and drilling industries by the National Institute of Occupational Safety and Health. Exposure to WC-Co is known to cause “hard metal lung disease” but the relationship between exposure, toxicity and development of disease remain poorly understood. To better understand this relationship, the present study examined the role of WC-Co particle size and internalization on toxicity using lung epithelial cells. We demonstrated that nano- and micro-WC-Co particles exerted toxicity in a dose- and time-dependent manner and that nano-WC-Co particles caused significantly greater toxicity at lower concentrations and shorter exposure times compared to micro-WC-Co particles. WC-Co particles in the nano-size range (not micron-sized) were internalized by lung epithelial cells, which suggested that internalization may play a key role in the enhanced toxicity of nano-WC-Co particles over micro-WC-Co particles. Further exploration of the internalization process indicated that there may be multiple mechanisms involved in WC-Co internalization such as actin and microtubule based cytoskeletal rearrangements. These findings support our hypothesis that WC-Co particle internalization contributes to cellular toxicity and suggests that therapeutic treatments inhibiting particle internalization may serve as prophylactic approaches for those at risk of WC-Co particle exposure.

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Section: Introductionmentioning

confidence: 99%

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

Armstead

Arena

2014

Toxicology and Applied Pharmacology

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“…Although cobalt itself was originally considered the causative agent of HMLD, several studies demonstrated that this is not the case and the disease mainly develops due to the simultaneous presence of WC with Co. 71,74,[76][77][78][79]90,91 It is currently understood that the combination of WC-Co is more toxic than Co, W, or WC particles alone, both in vitro and in vivo, 71,72,74,78,79,81,85,90,91,93,94,[97][98][99] but the reason for this enhanced toxicity is still not well defined.…”

Section: Risk Of Wc-co Exposure: Hard Metal Lung Disease (Hmld) Prognmentioning

confidence: 99%

Nanotoxicity: emerging concerns regarding nanomaterial safety and occupational hard metal (WC-Co) nanoparticle exposure

Armstead¹,

Li²

2016

IJN

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“…KERFOOT et al [18] exposed mini-pigs for 3 months to cobalt concentrations of 0.1 and 1.0 mg·m -3 . In view of a possible involvement of an immunological mechanism (a type I allergic reaction has been suggested in cobalt asthma), they first submitted the animals to a "sensitization" period by inhalation.…”

Section: Animal Studiesmentioning

confidence: 99%

Experimental research into the pathogenesis of cobalt/hard metal lung disease

Lison¹,

Lauwerys²,

Demedts³

et al. 1996

Eur Respir J

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In recent years clinical, epidemiological and experimental evidence has accumulated indicating that cobalt metal particles, when inhaled in association with other agents such as metallic carbides (hard metals) or diamond dust, may produce an interstitial lung disease termed "hard metal disease" or "cobalt lung". This article summarizes the progress accomplished in our two laboratories to understand the pathogenesis of this disease. Gaps and weaknesses in our current knowledge have also been highlighted in order to suggest potential avenues for further research. Whilst animal models have proved useful for the demonstration of the toxic synergy between cobalt and carbides (e.g. tungsten carbide), most animal models have remained descriptive and have not provided information on the mechanism for this synergy. In particular, the bizarre multinucleated giant cells which are an important hallmark of the human disease, have not been reproduced consistently in experimental animals. Since cobalt is a known sensitizer, there may also be a need to develop experimental models to test the possible involvement of immunological mechanisms in the pathogenesis of the interstitial disease. In vitro systems including macrophage cell cultures and physico-chemical tests have been useful to investigate the mechanism underlying the toxic synergy.The recent finding that, in vitro, cobalt and metallic carbides interact with oxygen to produce toxic activated oxygen species opens a new avenue of research and may offer an alternative interpretation of the fact that only a limited proportion of exposed workers develop interstitial disease. Besides the possible involvement of immunological mechanisms, it may be speculated that individuals with a lower antioxidant defence are more susceptible to the toxic effect of activated oxygen species produced by cobalt-containing dusts from hard metal.

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Cobalt Metal Inhalation Studies on Miniature Swine

Cited by 65 publications

References 0 publications

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

Nanotoxicity: emerging concerns regarding nanomaterial safety and occupational hard metal (WC-Co) nanoparticle exposure

Experimental research into the pathogenesis of cobalt/hard metal lung disease

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