Cobalt-nickel alloy nanoparticles surface-functionalized with cyclodextrin for delivering 5-fluorouracil

Akash, Bose Allben; Kanagaraj, Suganya; Sumathi, S.; Varalakshmi, Govindaraj Sri; Manikantan, Varnitha; Pillai, Archana Sumohan; Alexander, Aleyamma; Enoch, Israel V.M.V.

doi:10.1016/j.molstruc.2023.135906

Cited by 4 publications

(3 citation statements)

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“…β-Cyclodextrin (β-CD) is a unique and important bio-compound that has received much research attention as an essential component in a variety of hybrids with various types of inorganic materials for both medicinal and environmental industries. , This was primarily attributed to its accessibility, biological compatibility, stable chemical composition, notable adsorption, and non-toxic qualities. , On a chemical basis, β-CD demonstrates a cyclic glucopyranose framework that is built up of 6 or 7 glucose subunits that are joined or linked to each other by different forms of α (1 → 4) glycosidic bond. , While the outside surfaces of these units and corresponding chemical groups show substantial polarity, the interior frameworks of β-CD possess hydrophobic characteristics . This promotes its incorporation into hybrid materials with inorganic components and the drug-loading capabilities of synthetic carriers depending on their physicochemical characteristics. , The β-CD considerably increases the drug’s physicochemical qualities, including its solubility in water, chemical resistance, therapeutic activity, and durability …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 35 , 36 On a chemical basis, β-CD demonstrates a cyclic glucopyranose framework that is built up of 6 or 7 glucose subunits that are joined or linked to each other by different forms of α (1 → 4) glycosidic bond. 34 , 37 While the outside surfaces of these units and corresponding chemical groups show substantial polarity, the interior frameworks of β-CD possess hydrophobic characteristics. 38 This promotes its incorporation into hybrid materials with inorganic components and the drug-loading capabilities of synthetic carriers depending on their physicochemical characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Mg–Hydroxyapatite and Its β-Cyclodextrin Composite as Enhanced Bio-Carrier of 5-Fluorouracil Drug; Equilibrium and Release Kinetics

Abukhadra,

Okasha,

Al Othman

et al. 2023

ACS Omega

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An advanced form of magnesium-doped hydroxyapatite (Mg·HAP) was integrated in composite with β-cyclodextrin producing a safe biocomposite (β-CD/HAP) as an enhanced delivery structure of traditional 5-fluorouracil (5-FU) chemotherapy during the treatment stages of colorectal cancer cells. The qualifications of β-CD/HAP as a carrier for 5-FU were followed based on the loading, release, and cytotoxicity as compared to Mg·HAP. β-CD/HAP composite exhibits notably higher 5-FU encapsulation capacity (272.3 mg/g) than Mg·HAP phase (164.9 mg/g). The 5-FU encapsulation processes into β-CD/HAP display the isotherm behavior of the Freundlich model (R 2 = 0.99) and kinetic assumptions of pseudo-first order kinetic (R 2 > 0.95). The steric studies reflect a strong increment in the quantities of the free sites after the β-CD integration steps (Nm = 61.2 mg/g) as compared to pure Mg·HAP (Nm = 42.4 mg/g). Also, the capacity of each site was enhanced to be loaded by 5 of 5-FU molecules (n = 4.45) in a vertical orientation. The 5-FU encapsulation energy into β-CD/HAP (<40 kJ/mol) reflects physical encapsulation reactions involving van der Waals forces and hydrogen bonding. The 5-FU release profiles of β-CD/HAP exhibit slow and controlled properties for about 80 h either in gastric fluid (pH 1.2) or in intestinal fluid (pH 7.4). The release kinetics and diffusion exponent (>0.45) signify non-Fickian transport and complex erosion/diffusion release mechanism. The free β-CD/HAP particles display a considerable cytotoxic effect on the HCT-116 cancer cells (33.62% cell viability) and its 5-FU-loaded product shows a strong cytotoxic effect (2.91% cell viability).

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